UniProt Accession

 RPAB4_YEAST; P40422; D3DL93 

Genbank Protein ID

 U23378; U10397; AY558549; BK006934 

Genbank Nucleotide ID

 AAA64417.1; AAB68994.1; AAS56875.1; DAA06837.1 

Protein Name

 DNA-directed RNA polymerases I, II, and III subunit RPABC4 

Protein Synonyms/Alias

 RNA polymerases I, II, and III subunit ABC4; ABC10-alpha 

Gene Name

 RPC10 

Gene Synonyms/Alias

 RPB12; YHR143W-A; YHR143BW 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
28	QARTATLKYICAECS	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pols are composed of mobile elements that move relative to each other. In Pol II, the core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center. 

Sequence Annotation

 ZN_FING 31 51 C4-type.
 METAL 31 31 Zinc.
 METAL 34 34 Zinc.
 METAL 48 48 Zinc.
 METAL 51 51 Zinc.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; DNA-directed RNA polymerase; Metal-binding; Nucleus; Reference proteome; Transcription; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 70 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005736; C:DNA-directed RNA polymerase I complex; IDA:SGD.
 GO:0005665; C:DNA-directed RNA polymerase II, core complex; IDA:SGD.
 GO:0005666; C:DNA-directed RNA polymerase III complex; IDA:SGD.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IDA:SGD.
 GO:0006360; P:transcription from RNA polymerase I promoter; IDA:SGD.
 GO:0006366; P:transcription from RNA polymerase II promoter; IMP:SGD.
 GO:0042797; P:tRNA transcription from RNA polymerase III promoter; IDA:SGD. 

Interpro

 IPR006591; RNAP_P/RPC10. 

Pfam

 PF03604; DNA_RNApol_7kD 

SMART

 SM00659; RPOLCX 

PROSITE

  

PRINTS