CPLM 1.0 - Compendium of Protein Lysine Modification
Tag
Content
CPLM ID
CPLM-042013
UniProt Accession
G5EA13_HUMAN
;
G5EA13
Genbank Protein ID
AC025370
;
CH471060
Genbank Nucleotide ID
EAW91869.1
Protein Name
Frizzled homolog 6 (Drosophila), isoform CRA_b
Protein Synonyms/Alias
Frizzled-6
Gene Name
FZD6
Gene Synonyms/Alias
hCG_15041
Created Date
July 27, 2013
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Lysine Modification
Position
Peptide
Type
References
191
PCPNMYF
K
SDELEFA
ubiquitination
[1]
Reference
[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [
PMID: 21906983
]
Functional Description
Sequence Annotation
Keyword
Complete proteome; Developmental protein; Disulfide bond; G-protein coupled receptor; Membrane; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix; Wnt signaling pathway.
Sequence Source
UniProt (SWISSPROT/TrEMBL); GenBank; EMBL
Protein Length
467 AA
Protein Sequence
MEMFTFLLTC IFLPLLRGHS LFTCEPITVP RCMKMAYNMT FFPNLMGHYD QSIAAVEMEH 60
FLPLANLECS PNIETFLCKA FVPTCIEQIH VVPPCRKLCE KVYSDCKKLI DTFGIRWPEE 120
LECDRLQYCD ETVPVTFDPH TEFLGPQKKT EQVQRDIGFW CPRHLKTSGG QGYKFLGIDQ 180
CAPPCPNMYF KSDELEFAKS FIGTVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC 240
YSIVSLMYFI GFLLGDSTAC NKADEKLELG DTVVLGSQNK ACTVLFMLLY FFTMAGTVWW 300
VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGTPGFLTV MLLAMNKVEG DNISGVCFVG 360
LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI QHDGRNQEKL KKFMIRIGVF 420
SGLYLVPLVT LLGCYVYEQV NRITWEITWV SDHCRQYHIP CPYQSNQ 467
Gene Ontology
GO:0016021
; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004930
; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO:0042813
; F:Wnt-activated receptor activity; IEA:InterPro.
GO:0007275
; P:multicellular organismal development; IEA:UniProtKB-KW.
GO:0016055
; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
Interpro
IPR000539
; Frizzled.
IPR015526
; Frizzled/SFRP.
IPR020067
; Frizzled_dom.
IPR026543
; FZD6.
IPR017981
; GPCR_2-like.
Pfam
PF01534
; Frizzled
PF01392
; Fz
SMART
SM00063
; FRI
PROSITE
PS50038
; FZ
PS50261
; G_PROTEIN_RECEP_F2_4
PRINTS
PR00489
; FRIZZLED.