CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043209
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 3-ketoacyl-CoA thiolase A, peroxisomal 
Protein Synonyms/Alias
  
Gene Name
 Acaa1a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
261MQGLAKLKPAFKDGGacetylation[1]
265AKLKPAFKDGGSTTAacetylation[1]
265AKLKPAFKDGGSTTAubiquitination[2]
292VLLARRSKAEELGLPacetylation[1, 3, 4]
292VLLARRSKAEELGLPsuccinylation[4]
292VLLARRSKAEELGLPubiquitination[2]
Reference
 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 373 AA 
Protein Sequence
MHRLQVVLGH LAGRPESSSA LQAAPCSARF PQASASDVVV VHGRRTPIGR ASRGGFKNTT 60
PDELLSAVLT AVLQDVRLKP EQLGDISVGN VLEPGAGAVM ARIAQFLSGI PETVPLSTVN 120
RQCSSGLQAV ANIAGGIRNG SYDIGMACGV ESMSLSGMGN PGNISSRLLE SEKARDCLTP 180
MGMTSENVAE RFGISRQKQD DFALASQQKA ASAQSRGCFR AEIVPVTTTV LDDKGDKKTI 240
TVSQDEGVRP STTMQGLAKL KPAFKDGGST TAGNSSQVSD GAAAVLLARR SKAEELGLPI 300
LGVLRSYAVV GVPPDVMGIG PAYAIPAALQ KAGRLLCGEA RNSCREGEPA GGCNSPGPPP 360
GLHGSKAGCH ATQ 373 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005777; C:peroxisome; TAS:MGI.
 GO:0003985; F:acetyl-CoA C-acetyltransferase activity; TAS:MGI.
 GO:0006631; P:fatty acid metabolic process; TAS:MGI. 
Interpro
 IPR002155; Thiolase.
 IPR016039; Thiolase-like.
 IPR016038; Thiolase-like_subgr.
 IPR020615; Thiolase_acyl_enz_int_AS.
 IPR020617; Thiolase_C.
 IPR020616; Thiolase_N. 
Pfam
 PF02803; Thiolase_C
 PF00108; Thiolase_N 
SMART
  
PROSITE
 PS00098; THIOLASE_1 
PRINTS