UniProt Accession

 F5H5P4_HUMAN; F5H5P4 

Genbank Protein ID

 AC010647; AC020895; AC020954; AC022156 

Genbank Nucleotide ID

  

Protein Name

 Proto-oncogene vav 

Protein Synonyms/Alias

  

Gene Name

 VAV1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
20	FLSTCCEKFGLKRSE	ubiquitination	[1, 2]
125	VSMPHFLKPLQRFLK	ubiquitination	[1, 2]
175	NLYQVFIKYKERFLV	ubiquitination	[1]
195	SQVESASKHLDRVAA	ubiquitination	[1, 2]
210	AREDVQMKLEECSQR	ubiquitination	[1, 2, 3]
238	VPMQRVLKYHLLLQE	ubiquitination	[1, 3]
248	LLLQELVKHTQEAME	ubiquitination	[1]
256	HTQEAMEKENLRLAL	ubiquitination	[1, 2, 3]
277	AQCVNEVKRDNETLR	ubiquitination	[1, 2, 3]
307	LAHYGRPKIDGELKI	ubiquitination	[1]
313	PKIDGELKITSVERR	ubiquitination	[1, 3]
332	RYAFLLDKALLICKR	ubiquitination	[1]
338	DKALLICKRRGDSYD	ubiquitination	[1]
347	RGDSYDLKDFVNLHS	ubiquitination	[1, 3]
480	DFPGTMKKDKLHRRA	ubiquitination	[1]
532	GDIVELTKAEAEQNW	ubiquitination	[1]
603	FLVRQRVKDAAEFAI	ubiquitination	[1]
619	IKYNVEVKHIKIMTA	ubiquitination	[1]
654	FYQQNSLKDCFKSLD	ubiquitination	[1, 3, 4]
673	FPFKEPEKRTISRPA	ubiquitination	[1, 2]
685	RPAVGSTKYFGTAKA	ubiquitination	[1, 4]
691	TKYFGTAKARYDFCA	ubiquitination	[1, 4]
707	DRSELSLKEGDIIKI	ubiquitination	[1]
713	LKEGDIIKILNKKGQ	ubiquitination	[1]
718	IIKILNKKGQQGWWR	ubiquitination	[1, 4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Metal-binding; Phosphoprotein; Reference proteome; SH3 domain; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 748 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 

Interpro

 IPR001715; CH-domain.
 IPR000219; DH-domain.
 IPR001331; GDS_CDC24_CS.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR000980; SH2.
 IPR001452; SH3_domain. 

Pfam

 PF00130; C1_1
 PF00169; PH
 PF00621; RhoGEF
 PF00017; SH2
 PF00018; SH3_1 

SMART

 SM00109; C1
 SM00233; PH
 SM00325; RhoGEF
 SM00252; SH2
 SM00326; SH3 

PROSITE

 PS00741; DH_1
 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS50001; SH2
 PS50002; SH3
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 

PRINTS

 PR00401; SH2DOMAIN.
 PR00452; SH3DOMAIN.