CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034498
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Inositol monophosphatase 1 
Protein Synonyms/Alias
  
Gene Name
 Impa1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
63LVTVTDQKVEKMLMSacetylation[1, 2, 3]
63LVTVTDQKVEKMLMSubiquitination[4]
66VTDQKVEKMLMSSIKacetylation[2]
73KMLMSSIKEKYPCHSacetylation[2]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 90 AA 
Protein Sequence
MSPALPKPSG LYTIMADPWQ ECMDYAVILA RQAGEMIREA LKNEMDVMIK SSPADLVTVT 60
DQKVEKMLMS SIKEKYPCHS FIGEESVAAG 90 
Gene Ontology
 GO:0005737; C:cytoplasm; ISO:MGI.
 GO:0008934; F:inositol monophosphate 1-phosphatase activity; ISO:MGI.
 GO:0042803; F:protein homodimerization activity; ISO:MGI.
 GO:0006020; P:inositol metabolic process; TAS:MGI.
 GO:0046855; P:inositol phosphate dephosphorylation; ISO:MGI.
 GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. 
Interpro
 IPR000760; Inositol_monophosphatase. 
Pfam
 PF00459; Inositol_P 
SMART
  
PROSITE
  
PRINTS
 PR00377; IMPHPHTASES.