UniProt Accession

 THRSP_RAT; P04143; Q63536 

Genbank Protein ID

 K01934; M33553 

Genbank Nucleotide ID

 AAA96608.1; AAA42099.1 

Protein Name

 Thyroid hormone-inducible hepatic protein 

Protein Synonyms/Alias

 Spot 14 protein; S14; SPOT14 

Gene Name

 Thrsp 

Gene Synonyms/Alias

 S14 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
15	YPKNCLLKVMDRYSA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Lipid biosynthesis; Lipid metabolism; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 150 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
 GO:0046890; P:regulation of lipid biosynthetic process; IMP:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR009786; Spot_14. 

Pfam

 PF07084; Spot_14 

SMART

  

PROSITE

  

PRINTS