CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031363
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleoside diphosphate kinase 7 
Protein Synonyms/Alias
 cDNA FLJ58336, highly similar to Nucleoside diphosphate kinase 7 (EC 2.7.4.6) 
Gene Name
 NME7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
41SVEMHDVKNHRTFLKubiquitination[1]
51RTFLKRTKYDNLHLEubiquitination[1, 2, 3]
65EDLFIGNKVNVFSRQubiquitination[1]
99EKTLALIKPDAISKAubiquitination[1]
105IKPDAISKAGEIIEIubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 339 AA 
Protein Sequence
MNHSERFVFI AEWYDPNASL LRRYELLFYP GDGSVEMHDV KNHRTFLKRT KYDNLHLEDL 60
FIGNKVNVFS RQLVLIDYGD QYTARQLGSR KEKTLALIKP DAISKAGEII EIINKAGFTI 120
TKLKMMMLSR KEALDFHVDH QSRPFFNELI QFITTGPIIA MEILRDDAIC EWKRLLGPAN 180
SGVARTDASE SIRALFGTDG IRNAAHGPDS FASAAREMEL FFPSSGGCGP ANTAKFTNCT 240
CCIVKPHAVS EGLLGKILMA IRDAGFEISA MQMFNMDRVN VEEFYEVYKG VVTEYHDMVT 300
EMYSGPCVAM EIQQNNATKT FREFCGPADP TPKSPISHK 339 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004550; F:nucleoside diphosphate kinase activity; IEA:InterPro.
 GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
 GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
 GO:0006228; P:UTP biosynthetic process; IEA:InterPro. 
Interpro
 IPR011410; NDK7.
 IPR001564; Nucleoside_diP_kinase.
 IPR006602; Uncharacterised_DM10. 
Pfam
 PF00334; NDK 
SMART
 SM00676; DM10
 SM00562; NDK 
PROSITE
 PS51336; DM10 
PRINTS
 PR01243; NUCDPKINASE.