UniProt Accession

 AOFA_MOUSE; Q64133; B1AX52; Q8K0Z8 

Genbank Protein ID

 AL805907; AL831729; AL831729; AL805907; CH466584; BC029100; S78615; S78606 

Genbank Nucleotide ID

 CAM18994.1; CAM18994.1; CAM26634.1; CAM26634.1; EDL35717.1; AAH29100.1; AAB34677.1; AAB34677.1 

Protein Name

 Amine oxidase [flavin-containing] A 

Protein Synonyms/Alias

 Monoamine oxidase type A; MAO-A 

Gene Name

 Maoa 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
61	TVRNEHVKWVDVGGA	ubiquitination	[1]
82	NRILRLSKELGIETY	ubiquitination	[1]
90	ELGIETYKVNVNERL	ubiquitination	[1]
136	RTMDDMGKEIPVDAP	ubiquitination	[1]
284	LTAKIHFKPELPPER	acetylation	[2, 3]
372	HKDIRKRKICELYAK	acetylation	[4]
372	HKDIRKRKICELYAK	ubiquitination	[1]
465	EVLNALGKVAKKDIW	acetylation	[3]
465	EVLNALGKVAKKDIW	succinylation	[3]
469	ALGKVAKKDIWVQEP	acetylation	[3]
469	ALGKVAKKDIWVQEP	ubiquitination	[1]
479	WVQEPESKDVPALEI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 

Functional Description

 Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). 

Sequence Annotation

 REGION 520 522 Interaction with membrane phospholipid
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 406 406 S-8alpha-FAD cysteine (By similarity).  

Keyword

 Acetylation; Catecholamine metabolism; Complete proteome; Direct protein sequencing; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion outer membrane; Neurotransmitter degradation; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 526 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
 GO:0042420; P:dopamine catabolic process; IDA:MGI.
 GO:0042135; P:neurotransmitter catabolic process; IEA:UniProtKB-KW. 

Interpro

 IPR002937; Amino_oxidase.
 IPR001613; Flavin_amine_oxidase. 

Pfam

 PF01593; Amino_oxidase 

SMART

  

PROSITE

  

PRINTS

 PR00757; AMINEOXDASEF.