CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032842
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 5-hydroxytryptamine (Serotonin) receptor 4 
Protein Synonyms/Alias
 5-hydroxytryptamine receptor 4 
Gene Name
 HTR4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
368GTETDRKKLWNKEEKubiquitination[1]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; G-protein coupled receptor; Membrane; Receptor; Reference proteome; Transducer; Transmembrane. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 411 AA 
Protein Sequence
MDKLDANVSS EEGFGSVEKV VLLTFLSTVI LMAILGNLLV MVAVCWDRQL RKIKTNYFIV 60
SLAFADLLVS VLVMPFGAIE LVQDIWIYGE VFCLVRTSLD VLLTTASIFH LCCISLDRYY 120
AICCQPLVYR NKMTPLRIAL MLGGCWVIPT FISFLPIMQG WNNIGIIDLI EKRKFNQNSN 180
STYCVFMVNK PYAITCSVVA FYIPFLLMVL AYYRIYVTAK EHAHQIQMLQ RAGASSESRP 240
QSADQHSTHR MRTETKAAKT LCIIMGCFCL CWAPFFVTNI VDPFIDYTVP GQVWTAFLWL 300
GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYRRPSIL GQTVPCSTTT INGSTHVLSS 360
GTETDRKKLW NKEEKIDQTI QMPKRKRKKK ASLSYEDLIL LGRKSCFREG K 411 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:InterPro.
 GO:0004993; F:serotonin receptor activity; IEA:InterPro.
 GO:0050890; P:cognition; IEA:InterPro.
 GO:0030816; P:positive regulation of cAMP metabolic process; IEA:InterPro.
 GO:0045761; P:regulation of adenylate cyclase activity; IEA:InterPro.
 GO:0032098; P:regulation of appetite; IEA:InterPro.
 GO:0007210; P:serotonin receptor signaling pathway; IEA:GOC.
 GO:0007268; P:synaptic transmission; IEA:InterPro. 
Interpro
 IPR001520; 5HT4_rcpt.
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM. 
Pfam
 PF00001; 7tm_1 
SMART
  
PROSITE
 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 
PRINTS
 PR01059; 5HT4RECEPTR.
 PR00237; GPCRRHODOPSN.