CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010788
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Receptor expression-enhancing protein 5 
Protein Synonyms/Alias
 Polyposis locus protein 1; Protein TB2 
Gene Name
 REEP5 
Gene Synonyms/Alias
 C5orf18; DP1; TB2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
16FDRFLHEKNCMTDLLubiquitination[1, 2]
147IIRPFFLKHESQMDSubiquitination[1, 2]
157SQMDSVVKDLKDKAKubiquitination[1, 2]
162VVKDLKDKAKETADAacetylation[3]
164KDLKDKAKETADAITacetylation[3]
172ETADAITKEAKKATVubiquitination[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 May promote functional cell surface expression of olfactory receptors. 
Sequence Annotation
 MOD_RES 162 162 N6-acetyllysine.
 MOD_RES 164 164 N6-acetyllysine.  
Keyword
 Acetylation; Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 189 AA 
Protein Sequence
MSAAMRERFD RFLHEKNCMT DLLAKLEAKT GVNRSFIALG VIGLVALYLV FGYGASLLCN 60
LIGFGYPAYI SIKAIESPNK EDDTQWLTYW VVYGVFSIAE FFSDIFLSWF PFYYMLKCGF 120
LLWCMAPSPS NGAELLYKRI IRPFFLKHES QMDSVVKDLK DKAKETADAI TKEAKKATVN 180
LLGEEKKST 189 
Gene Ontology
 GO:0016021; C:integral to membrane; NAS:UniProtKB. 
Interpro
 IPR004345; TB2_DP1_HVA22. 
Pfam
 PF03134; TB2_DP1_HVA22 
SMART
  
PROSITE
  
PRINTS