| Tag | Content |
|---|
| CPLM ID | CPLM-006854 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lipid droplet hydrolase 1 |
Protein Synonyms/Alias | Lipid esterase; Triacylglycerol lipase |
Gene Name | LDH1 |
Gene Synonyms/Alias | YBR204C; YBR1444 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 11 | AERAEATKSWSCEPL | ubiquitination | [1] | | 309 | VLTQTDMKQKIIIFG | ubiquitination | [1] | | 337 | FYKQTINKECLRKVI | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Serine hydrolase required for the maintenance of steady state level of non-polar and polar lipids of lipid droplets and thus plays a role in maintaining the lipids homeostasis. Exhibits both esterase and triacylglycerol lipase activity. |
Sequence Annotation | MOTIF 373 375 Microbody targeting signal (Potential).
ACT_SITE 177 177 By similarity.
ACT_SITE 351 351 By similarity. |
Keyword | Complete proteome; Hydrolase; Lipid degradation; Lipid droplet; Lipid metabolism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 375 AA |
Protein Sequence | MNMAERAEAT KSWSCEPLSG KTLEEIVQNA ENAADLVAYI RKPEVDLDFR LKFIAEHEEF 60
FNVQLSDRNS RIRTCHNLSD KGIRGDTVFV FVPGLAGNLE QFEPLLELVD SDQKAFLTLD 120
LPGFGHSSEW SDYPMLKVVE LIFVLVCDVL RKWSTAVPNN DNVNPFNGHK IVLVGHSMGC 180
FLACHLYEQH MADTKAVQTL VLLTPPKAHI EQLSKDKHII QWALYGVFKL PWLFDVYRNK 240
FDQVKGLQSS GIKQYFYQQG DDVKLKYRKF WQFKNNISNK SRTIIGYLLG WETVDWVKFN 300
GVLTQTDMKQ KIIIFGAEKD PIAPIENLEF YKQTINKECL RKVIILPDCS HNLCFDRPEL 360
VCENFQREVI DNSKL 375 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |