CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015657
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GPI inositol-deacylase 
Protein Synonyms/Alias
 Post-GPI attachment to proteins factor 1; hPGAP1 
Gene Name
 PGAP1 
Gene Synonyms/Alias
 UNQ3024/PRO9822 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
187ARALLTLKNFKHDLIubiquitination[1]
308DLIDADTKQITQNSKubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi (By similarity). 
Sequence Annotation
 ACT_SITE 174 174 By similarity.
 CARBOHYD 402 402 N-linked (GlcNAc...) (Potential).
 CARBOHYD 558 558 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Endoplasmic reticulum; Glycoprotein; Hydrolase; Membrane; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 922 AA 
Protein Sequence
MFLHSVNLWN LAFYVFMVFL ATLGLWDVFF GFEENKCSMS YMFEYPEYQK IELPKKLAKR 60
YPAYELYLYG EGSYAEEHKI LPLTGIPVLF LPGNAGSYKQ VRSIGSIALR KAEDIDFKYH 120
FDFFSVNFNE ELVALYGGSL QKQTKFVHEC IKTILKLYKG QEFAPKSVAI IGHSMGGLVA 180
RALLTLKNFK HDLINLLITQ ATPHVAPVMP LDRFITDFYT TVNNYWILNA RHINLTTLSV 240
AGGFRDYQVR SGLTFLPKLS HHTSALSVVS SAVPKTWVST DHLSIVWCKQ LQLTTVRAFF 300
DLIDADTKQI TQNSKKKLSV LYHHFIRHPS KHFEENPAII SDLTGTSMWV LVKVSKWTYV 360
AYNESEKIYF TFPLENHRKI YTHVYCQSTM LDTNSWIFAC INSTSMCLQG VDLSWKAELL 420
PTIKYLTLRL QDYPSLSHLV VYVPSVRGSK FVVDCEFFKK EKRYIQLPVT HLFSFGLSSR 480
KVVLNTNGLY YNLELLNFGQ IYQAFKINVV SKCSAVKEEI TSIYRLHIPW SYEDSLTIAQ 540
APSSTEISLK LHIAQPENNT HVALFKMYTS SDCRYEVTVK TSFSQILGQV VRFHGGALPA 600
YVVSNILLAY RGQLYSLFST GCCLEYATML DKEAKPYKVD PFVIIIKFLL GYKWFKELWD 660
VLLLPELDAV ILTCQSMCFP LISLILFLFG TCTAYWSGLL SSASVRLLSS LWLALKRPSE 720
LPKDIKMISP DLPFLTIVLI IVSWTTCGAL AILLSYLYYV FKVVHLQASL TTFKNSQPVN 780
PKHSRRSEKK SNHHKDSSIH HLRLSANDAE DSLRMHSTVI NLLTWIVLLS MPSLIYWLKN 840
LRYYFKLNPD PCKPLAFILI PTMAILGNTY TVSIKSSKLL KTTSQFPLPL AVGVIAFGSA 900
HLYRLPCFVF IPLLLHALCN FM 922 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004518; F:nuclease activity; ISS:UniProtKB.
 GO:0042578; F:phosphoric ester hydrolase activity; ISS:UniProtKB.
 GO:0009948; P:anterior/posterior axis specification; IEA:Compara.
 GO:0016255; P:attachment of GPI anchor to protein; TAS:Reactome.
 GO:0006501; P:C-terminal protein lipidation; TAS:Reactome.
 GO:0009880; P:embryonic pattern specification; IEA:Compara.
 GO:0021871; P:forebrain regionalization; IEA:Compara.
 GO:0060322; P:head development; IEA:Compara.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0015798; P:myo-inositol transport; ISS:UniProtKB.
 GO:0007605; P:sensory perception of sound; IEA:Compara. 
Interpro
 IPR012908; PGAP1-like. 
Pfam
 PF07819; PGAP1 
SMART
  
PROSITE
 PS00120; LIPASE_SER 
PRINTS