UniProt Accession

 1433Z_RAT; P63102; P35215; P70197; P97286; Q52KK1; Q6IRF4 

Genbank Protein ID

 D17615; U37252; D30740; BC070941; BC094305; L07913 

Genbank Nucleotide ID

 BAA04534.1; AAA80544.1; BAA06402.1; AAH70941.2; AAH94305.1; AAC37660.1 

Protein Name

 14-3-3 protein zeta/delta 

Protein Synonyms/Alias

 Mitochondrial import stimulation factor S1 subunit; Protein kinase C inhibitor protein 1; KCIP-1 

Gene Name

 Ywhaz 

Gene Synonyms/Alias

 Msfs1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
3	*****MDKNELVQKA	acetylation	[1]
3	*****MDKNELVQKA	ubiquitination	[2]
9	DKNELVQKAKLAEQA	acetylation	[1]
9	DKNELVQKAKLAEQA	ubiquitination	[2]
11	NELVQKAKLAEQAER	ubiquitination	[2]
49	NLLSVAYKNVVGARR	acetylation	[1]
68	VVSSIEQKTEGAEKK	acetylation	[1]
68	VVSSIEQKTEGAEKK	ubiquitination	[2]
74	QKTEGAEKKQQMARE	acetylation	[1]
115	NASQPESKVFYLKMK	acetylation	[1]
120	ESKVFYLKMKGDYYR	ubiquitination	[2]
122	KVFYLKMKGDYYRYL	ubiquitination	[2]
138	EVAAGDDKKGIVDQS	acetylation	[1]
138	EVAAGDDKKGIVDQS	ubiquitination	[2]
139	VAAGDDKKGIVDQSQ	ubiquitination	[2]
157	QEAFEISKKEMQPTH	acetylation	[1]
157	QEAFEISKKEMQPTH	ubiquitination	[2]
158	EAFEISKKEMQPTHP	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 3 3 N6-acetyllysine (By similarity).
 MOD_RES 58 58 Phosphoserine; by PKA (By similarity).
 MOD_RES 68 68 N6-acetyllysine (By similarity).
 MOD_RES 184 184 Phosphoserine (By similarity).
 MOD_RES 207 207 Phosphoserine (By similarity).
 MOD_RES 232 232 Phosphothreonine; by CK1 (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 245 AA 

Protein Sequence

Gene Ontology

 GO:0031252; C:cell leading edge; IDA:RGD.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
 GO:0014069; C:postsynaptic density; IDA:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0019904; F:protein domain specific binding; ISS:UniProtKB.
 GO:0002553; P:histamine secretion by mast cell; IMP:RGD.
 GO:0006626; P:protein targeting to mitochondrion; IDA:RGD.
 GO:0010941; P:regulation of cell death; IEA:Compara. 

Interpro

 IPR000308; 14-3-3.
 IPR023409; 14-3-3_CS.
 IPR023410; 14-3-3_domain. 

Pfam

 PF00244; 14-3-3 

SMART

 SM00101; 14_3_3 

PROSITE

 PS00796; 1433_1
 PS00797; 1433_2 

PRINTS

 PR00305; 1433ZETA.