UniProt Accession

 IRK1_HUMAN; P48048; B2RMR4; Q6LD67 

Genbank Protein ID

 U12541; U12542; U12543; U12544; U12545; U03884; U65406; U65406; U65406; CH471065; BC074752; BC136360; BC136361; S78737 

Genbank Nucleotide ID

 AAA61712.1; AAA61713.1; AAA61714.1; AAA61715.1; AAA61716.1; AAA20594.1; AAC51220.1; AAC51221.1; AAC51222.1; EAW67724.1; AAH74752.1; AAI36361.1; AAI36362.1; AAB35012.1 

Protein Name

 ATP-sensitive inward rectifier potassium channel 1 

Protein Synonyms/Alias

 ATP-regulated potassium channel ROM-K; Inward rectifier K(+) channel Kir1.1; Potassium channel, inwardly rectifying subfamily J member 1 

Gene Name

 KCNJ1 

Gene Synonyms/Alias

 ROMK1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
202	SKNAVISKRGGKLCL	acetylation	[1]

Reference

 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 

Functional Description

 In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. 

Sequence Annotation

 NP_BIND 223 230 ATP (Potential).
 MOTIF 141 146 Selectivity filter (By similarity).
 MOD_RES 44 44 Phosphoserine; by SGK1.
 CARBOHYD 117 117 N-linked (GlcNAc...).  

Keyword

 Alternative splicing; ATP-binding; Bartter syndrome; Cell membrane; Complete proteome; Disease mutation; Glycoprotein; Ion channel; Ion transport; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Potassium; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 391 AA 

Protein Sequence

Gene Ontology

 GO:0008076; C:voltage-gated potassium channel complex; TAS:ProtInc.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005242; F:inward rectifier potassium channel activity; TAS:ProtInc.
 GO:0072358; P:cardiovascular system development; IEA:Compara.
 GO:0007588; P:excretion; TAS:ProtInc.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:1900128; P:regulation of G-protein activated inward rectifier potassium channel activity; IEA:Compara.
 GO:0070294; P:renal sodium ion absorption; IEA:Compara.
 GO:0007268; P:synaptic transmission; TAS:Reactome.
 GO:0001894; P:tissue homeostasis; IEA:Compara. 

Interpro

 IPR014756; Ig_E-set.
 IPR016449; K_chnl_inward-rec_Kir.
 IPR003268; K_chnl_inward-rec_Kir1.1.
 IPR013518; K_chnl_inward-rec_Kir_cyto. 

Pfam

 PF01007; IRK 

SMART

  

PROSITE

  

PRINTS

 PR01321; KIR11CHANNEL.
 PR01320; KIRCHANNEL.