CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031072
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphoribosyl pyrophosphate synthase-associated protein 1 
Protein Synonyms/Alias
 cDNA FLJ57408, highly similar to Phosphoribosyl pyrophosphatesynthetase-associated protein 1 
Gene Name
 PRPSAP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
29IPYFPYSKQSKMRKRubiquitination[1]
102RNAVIVAKSPDAAKRubiquitination[2]
164PLMMAKEKPPITVVGubiquitination[1, 2, 3, 4]
248VQKLQCPKIKTVDISubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 282 AA 
Protein Sequence
MELLIMAYAL KTACARNIIG VIPYFPYSKQ SKMRKRGSIV CKLLASMLAK AGLTHIITMD 60
LHQKEIQGFF SFPVDNLRAS PFLLQYIQEE IPNYRNAVIV AKSPDAAKRA QSYAERLRLG 120
LAVIHGEAQC TELDMDDGRH SPPMVKNATV HPGLELPLMM AKEKPPITVV GDVGGRIAII 180
VDDIIDDVES FVAAAEILKE RGAYKIYVMA THGILSAEAP RLIEESSVDE VVVTNTVPHE 240
VQKLQCPKIK TVDISLILSE AIRRIHNGES MAYLFRNITV DD 282 
Gene Ontology
 GO:0002189; C:ribose phosphate diphosphokinase complex; IEA:Compara.
 GO:0030234; F:enzyme regulator activity; IEA:Compara.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0004749; F:ribose phosphate diphosphokinase activity; IEA:InterPro.
 GO:0033673; P:negative regulation of kinase activity; IEA:Compara.
 GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro. 
Interpro
 IPR005946; Rib-P_diPkinase. 
Pfam
  
SMART
  
PROSITE
  
PRINTS