CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044423
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cell division cycle 7-related protein kinase 
Protein Synonyms/Alias
  
Gene Name
 CDC7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
151GIVHRDVKPSNFLYNubiquitination[1]
163LYNRRLKKYALVDFGubiquitination[1]
179AQGTHDTKIELLKFVubiquitination[1]
184DTKIELLKFVQSEAQubiquitination[1, 2]
199QERCSQNKSHIITGNubiquitination[1]
207SHIITGNKIPLSGPVubiquitination[1]
225LDQQSTTKASVKRPYubiquitination[1]
246IKQGKDGKEGSVGLSubiquitination[1]
284VKLMKQSKTVDVLSRubiquitination[1]
303KKKAISTKVMNSAVMubiquitination[1]
312MNSAVMRKTASSCPAubiquitination[1, 3]
330CDCYATDKVCSICLSubiquitination[1]
413RETIQAAKTFGKSILubiquitination[1, 3]
417QAAKTFGKSILCSKEubiquitination[1]
423GKSILCSKEVPAQDLacetylation[3]
423GKSILCSKEVPAQDLubiquitination[1]
464HQPAISEKTDHKASCubiquitination[1]
542ALLHPFFKDMSL***ubiquitination[1, 3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 546 AA 
Protein Sequence
MEASLGIQMD EPMAFSPQRD RFQAEGSLKK NEQNFKLAGT FSSVYLATAQ LQVGPEEKIA 60
LKHLIPTSHP IRIAAELQCL TVAGGQDNVM GVKYCFRKND HVVIAMPYLE HESFLDILNS 120
LSFQEVREYM LNLFKALKRI HQFGIVHRDV KPSNFLYNRR LKKYALVDFG LAQGTHDTKI 180
ELLKFVQSEA QQERCSQNKS HIITGNKIPL SGPVPKELDQ QSTTKASVKR PYTNAQIQIK 240
QGKDGKEGSV GLSVQRSVFG ERNFNIHSSI SHESPAVKLM KQSKTVDVLS RKLATKKKAI 300
STKVMNSAVM RKTASSCPAS LTCDCYATDK VCSICLSRRQ QVAPRAGTPG FRAPEVLTKC 360
PNQTTAIDMW SAGVIFLSLL SGRYPFYKAS DDLTALAQIM TIRGSRETIQ AAKTFGKSIL 420
CSKEVPAQDL RKLCERLRGM DSSTPKLTSD IQGHASHQPA ISEKTDHKAS CLVQTPPGQY 480
SGNSFKKGDS NSCEHCFDEY NTNLEGWNEV PDEAYDLLDK LLDLNPASRI TAEEALLHPF 540
FKDMSL 546 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS