| Tag | Content |
|---|
| CPLM ID | CPLM-012492 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | P2Y purinoceptor 6 |
Protein Synonyms/Alias | P2Y6 |
Gene Name | P2RY6 |
Gene Synonyms/Alias | PP2891 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 322 | LLQKLTAKWQRQGR* | ubiquitination | [1] |
|
Reference | [1] Global identification of modular cullin-RING ligase substrates. Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ. Cell. 2011 Oct 14;147(2):459-74. [ PMID: 21963094] |
Functional Description | Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. |
Sequence Annotation | CARBOHYD 5 5 N-linked (GlcNAc...) (Potential).
DISULFID 99 177 By similarity. |
Keyword | 3D-structure; Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 328 AA |
Protein Sequence | MEWDNGTGQA LGLPPTTCVY RENFKQLLLP PVYSAVLAAG LPLNICVITQ ICTSRRALTR 60
TAVYTLNLAL ADLLYACSLP LLIYNYAQGD HWPFGDFACR LVRFLFYANL HGSILFLTCI 120
SFQRYLGICH PLAPWHKRGG RRAAWLVCVA VWLAVTTQCL PTAIFAATGI QRNRTVCYDL 180
SPPALATHYM PYGMALTVIG FLLPFAALLA CYCLLACRLC RQDGPAEPVA QERRGKAARM 240
AVVVAAAFAI SFLPFHITKT AYLAVRSTPG VPCTVLEAFA AAYKGTRPFA SANSVLDPIL 300
FYFTQKKFRR RPHELLQKLT AKWQRQGR 328 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:Compara. GO:0016323; C:basolateral plasma membrane; IEA:Compara. GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0045028; F:G-protein coupled purinergic nucleotide receptor activity; IEA:InterPro. GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc. GO:0045029; F:UDP-activated nucleotide receptor activity; IEA:Compara. GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; TAS:ProtInc. GO:0014911; P:positive regulation of smooth muscle cell migration; IEA:Compara. GO:0030321; P:transepithelial chloride transport; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |