UniProt Accession

 SPCS2_MOUSE; Q9CYN2; Q3THR2; Q80X74; Q921V8; Q9CXK1 

Genbank Protein ID

 AK014310; AK017504; AK077510; AK134578; AK168173; BC010547; BC050150 

Genbank Nucleotide ID

 BAB29262.1; BAB30777.1; BAC36836.1; BAE22190.1; BAE40134.1; AAH10547.2; AAH50150.1 

Protein Name

 Signal peptidase complex subunit 2 

Protein Synonyms/Alias

 Microsomal signal peptidase 25 kDa subunit; SPase 25 kDa subunit 

Gene Name

 Spcs2 

Gene Synonyms/Alias

 Spc25 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
191	QREAEFTKSIAKFFD	acetylation	[1, 2]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 169 169 N6-acetyllysine (By similarity).
 MOD_RES 191 191 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Endoplasmic reticulum; Hydrolase; Membrane; Microsome; Protease; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 226 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005787; C:signal peptidase complex; IEA:InterPro.
 GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0006465; P:signal peptide processing; IEA:InterPro. 

Interpro

 IPR009582; SigPept_cplx_su2. 

Pfam

 PF06703; SPC25 

SMART

  

PROSITE

  

PRINTS