| Tag | Content |
|---|
| CPLM ID | CPLM-007818 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription initiation factor TFIID subunit 1 |
Protein Synonyms/Alias | TAFII-130; TAFII-145; TBP-associated factor 1; TBP-associated factor 145 kDa |
Gene Name | TAF1 |
Gene Synonyms/Alias | TAF130; TAF145; YGR274C; G9374 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 280 | VAPIYQGKNNLLQSN | ubiquitination | [1] | | 1025 | LAGVTDGKAARNKGK | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre- initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. |
Sequence Annotation | |
Keyword | Acyltransferase; Chromatin regulator; Coiled coil; Complete proteome; Direct protein sequencing; Nucleus; Reference proteome; Transcription; Transcription regulation; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1066 AA |
Protein Sequence | MVKQQGSGKT NLANEDEAYE AIFGGEFGSL EIGSYIGGDE GANSKDYTEH LPDAVDFEDE 60
DELADDDDDL PEESDANLHP AMMTMGAYDD VNENGAVLGI DSNSLNMQLP EINGDLSQQF 120
ILEDDGGTPA TSNALFMGMD ANEIHLATET GVLDGSGANE IGHSQLSIGG VNGNDMSING 180
GFIMEPDMSD GKHKKATKLD LINHEKYLLK KYFPDFEKGK ILKWNKLIYR RSVPYHWHSE 240
ISRVKKPFMP LNLKFKVQQD DKRLFNSRTI SYVAPIYQGK NNLLQSNSSA SRRGLIHVSI 300
DELFPIKEQQ KKRKIIHDEK TISEDLLIAT DDWDQEKIIN QGTSSTATLA DSSMTPNLKF 360
SGGYKLKSLI EDVAEDWQWD EDMIIDAKLK ESKHAELNMN DEKLLLMIEK TNNLAQQKQQ 420
LDSSNLILPL NETILQQKFN LSNDDKYQIL KKTHQTKVRS TISNLNIQHS QPAINLQSPF 480
YKVAVPRYQL RHFHRENFGS HIRPGTKIVF SKLKARKRKR DKGKDVKESF STSQDLTIGD 540
TAPVYLMEYS EQTPVALSKF GMANKLINYY RKANEQDTLR PKLPVGETHV LGVQDKSPFW 600
NFGFVEPGHI VPTLYNNMIR APVFKHDISG TDFLLTKSSG FGISNRFYLR NINHLFTVGQ 660
TFPVEEIPGP NSRKVTSMKA TRLKMIIYRI LNHNHSKAIS IDPIAKHFPD QDYGQNRQKV 720
KEFMKYQRDG PEKGLWRLKD DEKLLDNEAV KSLITPEQIS QVESMSQGLQ FQEDNEAYNF 780
DSKLKSLEEN LLPWNITKNF INSTQMRAMI QIHGVGDPTG CGEGFSFLKT SMKGGFVKSG 840
SPSSNNNSSN KKGTNTHSYN VAQQQKAYDE EIAKTWYTHT KSLSISNPFE EMTNPDEINQ 900
TNKHVKTDRD DKKILKIVRK KRDENGIIQR QTIFIRDPRV IQGYIKIKEQ DKEDVNKLLE 960
EDTSKINNLE ELEKQKKLLQ LELANLEKSQ QRRAARQNSK RNGGATRTEN SVDNGSDLAG 1020
VTDGKAARNK GKNTTRRCAT CGQIGHIRTN KSCPMYSSKD NPASPK 1066 |
Gene Ontology | GO:0005829; C:cytosol; IDA:SGD. GO:0005669; C:transcription factor TFIID complex; IDA:SGD. GO:0003682; F:chromatin binding; IDA:SGD. GO:0004402; F:histone acetyltransferase activity; IDA:SGD. GO:0003676; F:nucleic acid binding; IEA:InterPro. GO:0032947; F:protein complex scaffold; IDA:SGD. GO:0017025; F:TBP-class protein binding; IDA:SGD. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0051123; P:RNA polymerase II transcriptional preinitiation complex assembly; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |