CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029719
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Proteasome subunit beta type-8 
Protein Synonyms/Alias
  
Gene Name
 PSMB8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
109YWERLLAKECRLYYLacetylation[1]
109YWERLLAKECRLYYLubiquitination[1, 2]
129ISVSAASKLLSNMMCubiquitination[1, 2]
155MICGWDKKGPGLYYVubiquitination[1, 2, 3]
228VVNMYHMKEDGWVKVubiquitination[2, 3]
234MKEDGWVKVESTDVSubiquitination[1, 2]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 252 AA 
Protein Sequence
MALLDVCGAP RGQRPESALP VAGSGRRSDP GHYSFSMRSP ELALPRGMKP TEFFQSLGGD 60
GERNVQIEMA HGTTTLAFKF QHGVIAAVDS RASAGSYINC QYWERLLAKE CRLYYLRNGE 120
RISVSAASKL LSNMMCQYRG MGLSMGSMIC GWDKKGPGLY YVDEHGTRLS GNMFSTGSGN 180
TYAYGVMDSG YRPNLSPEEA YDLGRRAIAY ATHRDSYSGG VVNMYHMKED GWVKVESTDV 240
SDLLHQYREA NQ 252 
Gene Ontology
 GO:0005839; C:proteasome core complex; IEA:InterPro.
 GO:0004298; F:threonine-type endopeptidase activity; IEA:InterPro.
 GO:0051603; P:proteolysis involved in cellular protein catabolic process; IEA:InterPro. 
Interpro
 IPR001353; Proteasome_sua/b.
 IPR023333; Proteasome_suB-type. 
Pfam
 PF00227; Proteasome 
SMART
  
PROSITE
 PS51476; PROTEASOME_B_2 
PRINTS