UniProt Accession

 NDKM_HUMAN; O00746; Q5U0M9 

Genbank Protein ID

 Y07604; BT019438; AE006463; Z97634; CH471112; BC004880; BC017067 

Genbank Nucleotide ID

 CAA68877.1; AAV38245.1; AAK61230.1; CAC37288.1; EAW85820.1; AAH04880.1; AAH17067.1 

Protein Name

 Nucleoside diphosphate kinase, mitochondrial 

Protein Synonyms/Alias

 NDK; NDP kinase, mitochondrial; Nucleoside diphosphate kinase D; NDPKD; nm23-H4 

Gene Name

 NME4 

Gene Synonyms/Alias

 NM23D 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
91	HYQDLRRKPFYPALI	acetylation	[1]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity). 

Sequence Annotation

 ACT_SITE 151 151 Pros-phosphohistidine intermediate (By
 BINDING 45 45 ATP (By similarity).
 BINDING 93 93 ATP (By similarity).
 BINDING 121 121 ATP (By similarity).
 BINDING 127 127 ATP (By similarity).
 BINDING 138 138 ATP (By similarity).
 BINDING 148 148 ATP (By similarity).  

Keyword

 3D-structure; ATP-binding; Complete proteome; Direct protein sequencing; Kinase; Magnesium; Metal-binding; Mitochondrion; Nucleotide metabolism; Nucleotide-binding; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 187 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
 GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004550; F:nucleoside diphosphate kinase activity; EXP:Reactome.
 GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
 GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
 GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome.
 GO:0009116; P:nucleoside metabolic process; TAS:ProtInc.
 GO:0006228; P:UTP biosynthetic process; IEA:InterPro. 

Interpro

 IPR001564; Nucleoside_diP_kinase.
 IPR023005; Nucleoside_diP_kinase_AS. 

Pfam

 PF00334; NDK 

SMART

 SM00562; NDK 

PROSITE

 PS00469; NDP_KINASES 

PRINTS

 PR01243; NUCDPKINASE.