CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010787
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit 
Protein Synonyms/Alias
 General glucose sensor subunit 1; Glycogen metabolism control protein GLC6; Trehalose synthase complex catalytic subunit TPS1; Trehalose-6-phosphate synthase; UDP-glucose-glucosephosphate glucosyltransferase 
Gene Name
 TPS1 
Gene Synonyms/Alias
 BYP1; CIF1; FDP1; GGS1; GLC6; TSS1; YBR126C; YBR0922 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
261PIGIDVDKFTDGLKKacetylation[1]
279QKRIQQLKETFKGCKacetylation[1]
298VDRLDYIKGVPQKLHacetylation[1]
459KKEVNWEKLYKYISKacetylation[1]
462VNWEKLYKYISKYTSubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6- phosphate and UDP-glucose in a two step process. Can function independently of the complex. 
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; Direct protein sequencing; Glycosyltransferase; Reference proteome; Stress response; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 495 AA 
Protein Sequence
MTTDNAKAQL TSSSGGNIIV VSNRLPVTIT KNSSTGQYEY AMSSGGLVTA LEGLKKTYTF 60
KWFGWPGLEI PDDEKDQVRK DLLEKFNAVP IFLSDEIADL HYNGFSNSIL WPLFHYHPGE 120
INFDENAWLA YNEANQTFTN EIAKTMNHND LIWVHDYHLM LVPEMLRVKI HEKQLQNVKV 180
GWFLHTPFPS SEIYRILPVR QEILKGVLSC DLVGFHTYDY ARHFLSSVQR VLNVNTLPNG 240
VEYQGRFVNV GAFPIGIDVD KFTDGLKKES VQKRIQQLKE TFKGCKIIVG VDRLDYIKGV 300
PQKLHAMEVF LNEHPEWRGK VVLVQVAVPS RGDVEEYQYL RSVVNELVGR INGQFGTVEF 360
VPIHFMHKSI PFEELISLYA VSDVCLVSST RDGMNLVSYE YIACQEEKKG SLILSEFTGA 420
AQSLNGAIIV NPWNTDDLSD AINEALTLPD VKKEVNWEKL YKYISKYTSA FWGENFVHEL 480
YSTSSSSTSS SATKN 495 
Gene Ontology
 GO:0005946; C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming); IMP:SGD.
 GO:0003825; F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity; IMP:SGD.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW.
 GO:0005992; P:trehalose biosynthetic process; IMP:SGD. 
Interpro
 IPR001830; Glyco_trans_20.
 IPR012766; Trehalose_OtsA. 
Pfam
 PF00982; Glyco_transf_20 
SMART
  
PROSITE
  
PRINTS