CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020359
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Guanine nucleotide-binding protein subunit beta-like protein 1 
Protein Synonyms/Alias
 G protein subunit beta-like protein 1; DGCRK3; WD repeat-containing protein 14; WD40 repeat-containing protein deleted in VCFS; WDVCF 
Gene Name
 GNB1L 
Gene Synonyms/Alias
 GY2; KIAA1645; WDR14; FKSG1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
91LSQGRDLKLCLWDLAubiquitination[1, 2]
148QILEMPSKTSVCALKubiquitination[2, 3]
157SVCALKPKADAKLGMubiquitination[2, 4]
161LKPKADAKLGMPMCLubiquitination[2]
220DLDFDSQKARGISGSubiquitination[2, 3, 4]
266VTIRPDRKILATAGWubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
 REPEAT 18 62 WD 1.
 REPEAT 65 105 WD 2.
 REPEAT 160 203 WD 3.
 REPEAT 206 245 WD 4.
 REPEAT 251 292 WD 5.
 REPEAT 293 326 WD 6.  
Keyword
 Alternative splicing; Complete proteome; Polymorphism; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 327 AA 
Protein Sequence
MTAPCPPPPP DPQFVLRGTQ SPVHALHFCE GAQAQGRPLL FSGSQSGLVH IWSLQTRRAV 60
TTLDGHGGQC VTWLQTLPQG RQLLSQGRDL KLCLWDLAEG RSAVVDSVCL ESVGFCRSSI 120
LAGGQPRWTL AVPGRGSDEV QILEMPSKTS VCALKPKADA KLGMPMCLRL WQADCSSRPL 180
LLAGYEDGSV VLWDVSEQKV CSRIACHEEP VMDLDFDSQK ARGISGSAGK ALAVWSLDWQ 240
QALQVRGTHE LTNPGIAEVT IRPDRKILAT AGWDHRIRVF HWRTMQPLAV LAFHSAAVQC 300
VAFTADGLLA AGSKDQRISL WSLYPRA 327 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0009898; C:internal side of plasma membrane; NAS:UniProtKB.
 GO:0007186; P:G-protein coupled receptor signaling pathway; NAS:UniProtKB.
 GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.
 GO:0035176; P:social behavior; IEA:Compara. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS