CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007658
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-dependent RNA helicase HrpA 
Protein Synonyms/Alias
  
Gene Name
 hrpA 
Gene Synonyms/Alias
 b1413; JW5905 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
38LHGVKKVKNPDAQQAacetylation[1]
52AIFQEMAKEIDQAAGacetylation[1]
312DTADALNKLNLRHTEacetylation[1]
485DEQASAYKLTPLGRQacetylation[1]
606TQLRQVVKELGIPVNacetylation[1]
641IGMKDADKQEYTGARacetylation[1]
662FPGSGLFKKPPKWVMacetylation[1]
663PGSGLFKKPPKWVMVacetylation[1]
666GLFKKPPKWVMVAELacetylation[1]
701PVAQHLIKRTYSEPHacetylation[1]
782EVEELEHKSRRRDILacetylation[1]
818RHFDSWWKKVSRETPacetylation[1]
832PDLLNFEKSMLIKEGacetylation[1]
845EGAEKISKLDYPNFWacetylation[1]
858FWHQGNLKLRLSYQFacetylation[1]
908ELVIALIKSLPKPVRacetylation[1]
1083LNIPSPIKYLHEKLPacetylation[1]
1088PIKYLHEKLPNKAKLacetylation[1]
1140GFAALHEKVRAELNDacetylation[1]
1218RYLQAIEKRLEKLAVacetylation[1]
1236RDRAQMLKVENVQQAacetylation[1]
1250AWQQWINKLPPARREacetylation[1]
1289TPYPISDKRILQAMEacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Not yet known. 
Sequence Annotation
 DOMAIN 87 250 Helicase ATP-binding.
 DOMAIN 274 444 Helicase C-terminal.
 NP_BIND 100 107 ATP (By similarity).
 MOTIF 197 200 DEAH box.  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1300 AA 
Protein Sequence
MTEQQKLTFT ALQQRLDSLM LRDRLRFSRR LHGVKKVKNP DAQQAIFQEM AKEIDQAAGK 60
VLLREAARPE ITYPDNLPVS QKKQDILEAI RDHQVVIVAG ETGSGKTTQL PKICMELGRG 120
IKGLIGHTQP RRLAARTVAN RIAEELKTEP GGCIGYKVRF SDHVSDNTMV KLMTDGILLA 180
EIQQDRLLMQ YDTIIIDEAH ERSLNIDFLL GYLKELLPRR PDLKIIITSA TIDPERFSRH 240
FNNAPIIEVS GRTYPVEVRY RPIVEEADDT ERDQLQAIFD AVDELSQESH GDILIFMSGE 300
REIRDTADAL NKLNLRHTEI LPLYARLSNS EQNRVFQSHS GRRIVLATNV AETSLTVPGI 360
KYVIDPGTAR ISRYSYRTKV QRLPIEPISQ ASANQRKGRC GRVSEGICIR LYSEDDFLSR 420
PEFTDPEILR TNLASVILQM TALGLGDIAA FPFVEAPDKR NIQDGVRLLE ELGAITTDEQ 480
ASAYKLTPLG RQLSQLPVDP RLARMVLEAQ KHGCVREAMI ITSALSIQDP RERPMDKQQA 540
SDEKHRRFHD KESDFLAFVN LWNYLGEQQK ALSSNAFRRL CRTDYLNYLR VREWQDIYTQ 600
LRQVVKELGI PVNSEPAEYR EIHIALLTGL LSHIGMKDAD KQEYTGARNA RFSIFPGSGL 660
FKKPPKWVMV AELVETSRLW GRIAARIDPE WVEPVAQHLI KRTYSEPHWE RAQGAVMATE 720
KVTVYGLPIV AARKVNYSQI DPALCRELFI RHALVEGDWQ TRHAFFRENL KLRAEVEELE 780
HKSRRRDILV DDETLFEFYD QRISHDVISA RHFDSWWKKV SRETPDLLNF EKSMLIKEGA 840
EKISKLDYPN FWHQGNLKLR LSYQFEPGAD ADGVTVHIPL PLLNQVEESG FEWQIPGLRR 900
ELVIALIKSL PKPVRRNFVP APNYAEAFLG RVKPLELPLL DSLERELRRM TGVTVDREDW 960
HWDQVPDHLK ITFRVVDDKN KKLKEGRSLQ DLKDALKGKV QETLSAVADD GIEQSGLHIW 1020
SFGQLPESYE QKRGNYKVKA WPALVDERDS VAIKLFDNPL EQKQAMWNGL RRLLLLNIPS 1080
PIKYLHEKLP NKAKLGLYFN PYGKVLELID DCISCGVDKL IDANGGPVWT EEGFAALHEK 1140
VRAELNDTVV DIAKQVEQIL TAVFNINKRL KGRVDMTMAL GLSDIKAQMG GLVYRGFVTG 1200
NGFKRLGDTL RYLQAIEKRL EKLAVDPHRD RAQMLKVENV QQAWQQWINK LPPARREDED 1260
VKEIRWMIEE LRVSYFAQQL GTPYPISDKR ILQAMEQISG 1300 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004004; F:ATP-dependent RNA helicase activity; ISS:EcoCyc.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0006397; P:mRNA processing; IMP:EcoCyc.
 GO:0009451; P:RNA modification; IMP:EcoliWiki. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR011709; DUF1605.
 IPR007502; Helicase-assoc_dom.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR024590; RNA_helic_ATP-dep_DEAH_HrpA_C.
 IPR010222; RNA_helicase_ATP-dep_DEAH_HrpA. 
Pfam
 PF00270; DEAD
 PF11898; DUF3418
 PF04408; HA2
 PF00271; Helicase_C
 PF07717; OB_NTP_bind 
SMART
 SM00382; AAA
 SM00487; DEXDc
 SM00847; HA2
 SM00490; HELICc 
PROSITE
 PS00690; DEAH_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS