UniProt Accession

 ACTS_HUMAN; P68133; P02568; P99020; Q5T8M9 

Genbank Protein ID

 J00068; M20543; AF182035; CR536516; CR541796; AL160004; CH471098; BC012597 

Genbank Nucleotide ID

 AAB59376.1; AAA60296.1; AAF02694.1; CAG38754.1; CAG46595.1; CAI19050.1; EAW69898.1; AAH12597.1 

Protein Name

 Actin, alpha skeletal muscle 

Protein Synonyms/Alias

 Alpha-actin-1 

Gene Name

 ACTA1 

Gene Synonyms/Alias

 ACTA 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
63	VGDEAQSKRGILTLK	malonylation	[1]
70	KRGILTLKYPIEHGI	ubiquitination	[2, 3]
86	TNWDDMEKIWHHTFY	ubiquitination	[2]
115	TEAPLNPKANREKMT	ubiquitination	[2]

Reference

 [1] The first identification of lysine malonylation substrates and its regulatory enzyme.
 Peng C, Lu Z, Xie Z, Cheng Z, Chen Y, Tan M, Luo H, Zhang Y, He W, Yang K, Zwaans BM, Tishkoff D, Ho L, Lombard D, He TC, Dai J, Verdin E, Ye Y, Zhao Y.
 Mol Cell Proteomics. 2011 Dec;10(12):M111.012658. [PMID: 21908771]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. 

Sequence Annotation

 MOD_RES 3 3 N-acetylaspartate (By similarity).
 MOD_RES 46 46 Methionine sulfoxide (By similarity).
 MOD_RES 55 55 Phosphotyrosine (By similarity).
 MOD_RES 63 63 N6-malonyllysine.
 MOD_RES 75 75 Tele-methylhistidine (By similarity).
 MOD_RES 93 93 Phosphotyrosine (By similarity).
 MOD_RES 242 242 Phosphotyrosine (By similarity).  

Keyword

 3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Methylation; Muscle protein; Nemaline myopathy; Nucleotide-binding; Oxidation; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 377 AA 

Protein Sequence

Gene Ontology

 GO:0005884; C:actin filament; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB.
 GO:0001725; C:stress fiber; IDA:UniProtKB.
 GO:0005865; C:striated muscle thin filament; IDA:UniProtKB.
 GO:0043531; F:ADP binding; TAS:UniProtKB.
 GO:0005524; F:ATP binding; TAS:UniProtKB.
 GO:0017022; F:myosin binding; TAS:UniProtKB.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:UniProtKB.
 GO:0016049; P:cell growth; IEA:Compara.
 GO:0030049; P:muscle filament sliding; TAS:Reactome.
 GO:0009991; P:response to extracellular stimulus; IEA:Compara.
 GO:0010226; P:response to lithium ion; IEA:Compara.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0048545; P:response to steroid hormone stimulus; IEA:Compara.
 GO:0043503; P:skeletal muscle fiber adaptation; IEA:Compara.
 GO:0048741; P:skeletal muscle fiber development; ISS:UniProtKB.
 GO:0030240; P:skeletal muscle thin filament assembly; IMP:UniProtKB. 

Interpro

 IPR004000; Actin-related.
 IPR020902; Actin/actin-like_CS.
 IPR004001; Actin_CS. 

Pfam

 PF00022; Actin 

SMART

 SM00268; ACTIN 

PROSITE

 PS00406; ACTINS_1
 PS00432; ACTINS_2
 PS01132; ACTINS_ACT_LIKE 

PRINTS

 PR00190; ACTIN.