UniProt Accession

 GHC1_MOUSE; Q9D6M3; Q3TRY1 

Genbank Protein ID

 AK010193; AK046874; AK048389; AK049313; AK155276; AK162400; BC037949 

Genbank Nucleotide ID

 BAB26760.1; BAC32903.1; BAC33318.1; BAC33676.1; BAE33159.1; BAE36895.1; AAH37949.1 

Protein Name

 Mitochondrial glutamate carrier 1 

Protein Synonyms/Alias

 GC-1; Glutamate/H(+) symporter 1; Solute carrier family 25 member 22 

Gene Name

 Slc25a22 

Gene Synonyms/Alias

 Gc1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
80	LTLVTPEKAIKLAAN	acetylation	[1]
83	VTPEKAIKLAANDFF	acetylation	[1]
83	VTPEKAIKLAANDFF	ubiquitination	[2]
96	FFRHQLSKDGQKLTL	acetylation	[1]
188	HGIAGLYKGLGATLL	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+) (By similarity). 

Sequence Annotation

 REPEAT 6 93 Solcar 1.
 REPEAT 101 214 Solcar 2.
 REPEAT 223 312 Solcar 3.  

Keyword

 Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat; Symport; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 323 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
 GO:0005313; F:L-glutamate transmembrane transporter activity; ISS:UniProtKB.
 GO:0015293; F:symporter activity; IEA:UniProtKB-KW. 

Interpro

 IPR002067; Mit_carrier.
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 

Pfam

 PF00153; Mito_carr 

SMART

  

PROSITE

 PS50920; SOLCAR 

PRINTS

 PR00926; MITOCARRIER.