UniProt Accession

 LDHC_HUMAN; P07864; D3DQY4; Q6GSG8; Q7Z7J4 

Genbank Protein ID

 J02938; AH002865; U13680; AY286300; CH471064; CH471064; BC019249; BC064388; BC090043 

Genbank Nucleotide ID

 AAA59507.1; AAA59508.1; AAA21348.1; AAP37402.1; EAW68392.1; EAW68394.1; AAH19249.3; AAH64388.1; AAH90043.1 

Protein Name

 L-lactate dehydrogenase C chain 

Protein Synonyms/Alias

 LDH-C; Cancer/testis antigen 32; CT32; LDH testis subunit; LDH-X 

Gene Name

 LDHC 

Gene Synonyms/Alias

 LDH3; LDHX 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
59	DVALDKLKGEMMDLQ	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Possible role in sperm motility. 

Sequence Annotation

 NP_BIND 29 57 NAD (By similarity).
 ACT_SITE 193 193 Proton acceptor (By similarity).
 BINDING 99 99 NAD (By similarity).
 BINDING 106 106 Substrate (By similarity).
 BINDING 138 138 NAD or substrate (By similarity).
 BINDING 169 169 Substrate (By similarity).
 BINDING 248 248 Substrate (By similarity).
 MOD_RES 301 301 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 332 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004459; F:L-lactate dehydrogenase activity; TAS:ProtInc.
 GO:0006754; P:ATP biosynthetic process; IEA:Compara.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
 GO:0019244; P:lactate biosynthetic process from pyruvate; IEA:Compara.
 GO:0019516; P:lactate oxidation; IEA:Compara.
 GO:0030317; P:sperm motility; IEA:Compara. 

Interpro

 IPR001557; L-lactate/malate_DH.
 IPR011304; L-lactate_DH.
 IPR018177; L-lactate_DH_AS.
 IPR022383; Lactate/malate_DH_C.
 IPR001236; Lactate/malate_DH_N.
 IPR015955; Lactate_DH/Glyco_Ohase_4_C.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF02866; Ldh_1_C
 PF00056; Ldh_1_N 

SMART

  

PROSITE

 PS00064; L_LDH 

PRINTS

 PR00086; LLDHDRGNASE.