CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008009
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Endothelin B receptor 
Protein Synonyms/Alias
 ET-B; ET-BR; Endothelin receptor non-selective type 
Gene Name
 Ednrb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
346LHLSRILKLTLYDQSubiquitination[1]
424KQSCLKFKANDHGYDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Essential component in the normal development of two neuronal crest-derived cell lineages. 
Sequence Annotation
 MOD_RES 305 305 Phosphoserine (By similarity).
 MOD_RES 419 419 Phosphoserine (By similarity).
 MOD_RES 439 439 Phosphotyrosine (By similarity).
 MOD_RES 440 440 Phosphoserine (By similarity).
 MOD_RES 441 441 Phosphoserine (By similarity).
 LIPID 402 402 S-palmitoyl cysteine (Potential).
 LIPID 403 403 S-palmitoyl cysteine (Potential).
 LIPID 405 405 S-palmitoyl cysteine (Potential).
 CARBOHYD 60 60 N-linked (GlcNAc...) (Potential).
 DISULFID 174 255 By similarity.  
Keyword
 Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Receptor; Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 442 AA 
Protein Sequence
MQSPASRCGR ALVALLLACG FLGVWGEKRG FPPAQATLSL LGTKEVMTPP TKTSWTRGSN 60
SSLMRSSAPA EVTKGGRGAG VPPRSFPPPC QRNIEISKTF KYINTIVSCL VFVLGIIGNS 120
TLLRIIYKNK CMRNGPNILI ASLALGDLLH IIIDIPINTY KLLAEDWPFG AEMCKLVPFI 180
QKASVGITVL SLCALSIDRY RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF 240
DMITSDYKGK PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA VFYTLMTCEM 300
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY DQSNPHRCEL 360
LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC LCCWCQTFEE KQSLEEKQSC 420
LKFKANDHGY DNFRSSNKYS SS 442 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0031965; C:nuclear membrane; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004962; F:endothelin receptor activity; IDA:MGI.
 GO:0017046; F:peptide hormone binding; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
 GO:0019934; P:cGMP-mediated signaling; IEA:Compara.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IEA:Compara.
 GO:0048484; P:enteric nervous system development; IDA:BHF-UCL.
 GO:0035645; P:enteric smooth muscle cell differentiation; IDA:BHF-UCL.
 GO:0042045; P:epithelial fluid transport; IEA:Compara.
 GO:0048246; P:macrophage chemotaxis; IEA:Compara.
 GO:0030318; P:melanocyte differentiation; IDA:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0032269; P:negative regulation of cellular protein metabolic process; IEA:Compara.
 GO:0014043; P:negative regulation of neuron maturation; IDA:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0001755; P:neural crest cell migration; IMP:MGI.
 GO:0007422; P:peripheral nervous system development; IMP:MGI.
 GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0060406; P:positive regulation of penile erection; IEA:Compara.
 GO:0001934; P:positive regulation of protein phosphorylation; IEA:Compara.
 GO:0035815; P:positive regulation of renal sodium excretion; IEA:Compara.
 GO:0035810; P:positive regulation of urine volume; IEA:Compara.
 GO:0007497; P:posterior midgut development; IMP:MGI.
 GO:0008217; P:regulation of blood pressure; IMP:MGI.
 GO:0050678; P:regulation of epithelial cell proliferation; IEA:Compara.
 GO:0006885; P:regulation of pH; IMP:MGI.
 GO:0051930; P:regulation of sensory perception of pain; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0048265; P:response to pain; IEA:Compara.
 GO:0019233; P:sensory perception of pain; IEA:Compara.
 GO:0042311; P:vasodilation; IEA:Compara.
 GO:0014826; P:vein smooth muscle contraction; IEA:Compara. 
Interpro
 IPR000499; Endthln_rcpt.
 IPR001112; ETB_rcpt.
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM. 
Pfam
 PF00001; 7tm_1 
SMART
  
PROSITE
 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 
PRINTS
 PR00571; ENDOTHELINBR.
 PR00366; ENDOTHELINR.
 PR00237; GPCRRHODOPSN.