| Tag | Content |
|---|
| CPLM ID | CPLM-000189 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 60 kDa SS-A/Ro ribonucleoprotein |
Protein Synonyms/Alias | 60 kDa Ro protein; 60 kDa ribonucleoprotein Ro; RoRNP; TROVE domain family member 2 |
Gene Name | Trove2 |
Gene Synonyms/Alias | Ssa2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 312 | CEKLSNEKLLKKARI | ubiquitination | [1] | | 342 | HGLRGKLKWIPDKDI | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation. |
Sequence Annotation | DOMAIN 16 369 TROVE.
REGION 120 284 RNA-binding (By similarity).
REGION 361 538 VWFA-like domain (By similarity).
METAL 378 378 Divalent metal cation (By similarity).
METAL 380 380 Divalent metal cation (By similarity).
METAL 445 445 Divalent metal cation (By similarity).
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 19 19 Phosphoserine (By similarity).
MOD_RES 224 224 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Direct protein sequencing; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 538 AA |
Protein Sequence | MEGSANQLQP LSETQVVNSE GGCVWQVTDM NRLRRFLCFG SEGGTYYIKE QKLGLENAEA 60
LIRLIEDGRG CEVIQEIKSF SQEGRTAKQE PLLFALAVCS QCADINTKQA AFKAVPEVCR 120
IPTHLFTFIQ FKKDLKESMK CGMWGRALRK AVADWYNEKG GMAVALVVTK YKQRNGWSHK 180
DLLRLSHLKP SSEGLAIVTK YITKGWKEVH EEYKEKALSV EAEKLLKYLE AVEKVKRTKD 240
DLEVIHLIEE HQLVREHLLT NHLKSKEVWK ALLQEMPLTA LLRNLGKMTA NSVLEPGNSE 300
VSLICEKLSN EKLLKKARIH PFHVLIALET YRAGHGLRGK LKWIPDKDIL QALDAAFYTT 360
FKTVEPTGKR FLLAVDVSAS MNQRALGSVL NASTVAAAMC MVVTRTEKES SVVAFACDMV 420
PFPVTTDMTL QQVLTAMNKV PAGNTDCSLP MIWAQKTDTA ADVFVVFTDN ETFAGQVHPA 480
VALREYRKKM DIPAKLIVCG MTSNGFTIAD PDDRGMLDMC GFDTAALDVI RNFTLDVI 538 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |