CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026206
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 RNA-binding protein EWS 
Protein Synonyms/Alias
  
Gene Name
 Ewsr1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
429YEDPPTAKAAVEWFDubiquitination[1]
438AVEWFDGKDFQGSKLacetylation[2]
438AVEWFDGKDFQGSKLubiquitination[1]
444GKDFQGSKLKVSLARacetylation[2, 3]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 661 AA 
Protein Sequence
MASTDYSTYS QAAAQQGYSA YTAQPTQGYA QTTQAYGQQS YGTYGQPTDV SYTQAQTTAT 60
YGQTAYATSY GQPPTVEGTS TGYSTPTAPQ AYSQPVQGYG TGTYDSTTAT VTTTQASYAA 120
QTAYGTQPAY PTYGQQPTAT APTRPQDGNK PAETSQPQSS TGGYNQPSLG YGQSNYSYPQ 180
VPGSYPMQPV TAPPSYPPTS YSSSQPTSYD QSSYSQQNTY GQPSSYGQQS SYGQQSSYGQ 240
QPPTSYPPQT GSYSQAPSQY SQQSSSYGQQ SSFRQDHPSS MGVYGQESGG FSGPGENRSL 300
SGPDNRGRGR GGFDRGGMSR GGRGGGRGGL GAGERGGFNK PGGPMDEGPD LDLGLPIDPD 360
EDSDNSAIYV QGLNDNVTLD DLADFFKQCG VVKMNKRTGQ PMIHIYLDKE TGKPKGDATV 420
SYEDPPTAKA AVEWFDGKDF QGSKLKVSLA RKKPPMNSMR GGMPPREGRG MPPPLRGGPG 480
GPGGPGGPMG RMGGRGGDRG GFPPRGPRGS RGNPSGGGNV QHRAGDWQCP NPGCGNQNFA 540
WRTECNQCKA PKPEGFLPPP FPPPGGDRGR GGPGGMRGGR GGLMDRGGPG GMFRGGRGGD 600
RGGFRGGRGM DRGGFGGGRR GGPGGPPGPL MEQMGGRRGG RGGPGKMDKG EHRQERRDRP 660
Y 661 
Gene Ontology
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR001876; Znf_RanBP2. 
Pfam
 PF00076; RRM_1
 PF00641; zf-RanBP 
SMART
 SM00360; RRM
 SM00547; ZnF_RBZ 
PROSITE
 PS50102; RRM
 PS01358; ZF_RANBP2_1
 PS50199; ZF_RANBP2_2 
PRINTS