CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014572
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RNA-binding protein Raly 
Protein Synonyms/Alias
 Maternally-expressed hnRNP C-related protein; hnRNP associated with lethal yellow protein 
Gene Name
 Raly 
Gene Synonyms/Alias
 Merc 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
165VKTTIPVKLFARSTAubiquitination[1]
179AVTTGSAKIKLKSSEubiquitination[1]
183GSAKIKLKSSELQTIubiquitination[1]
216EQIAEEQKANPDGKKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Probable-RNA binding protein. Could be a heterogeneous nuclear ribonucleoprotein (hnRNP). May be involved in pre-mRNA splicing (By similarity). 
Sequence Annotation
 DOMAIN 21 92 RRM.
 MOD_RES 135 135 Phosphoserine.
 MOD_RES 165 165 N6-acetyllysine (By similarity).
 MOD_RES 268 268 Phosphothreonine.
 MOD_RES 270 270 Phosphoserine.
 MOD_RES 274 274 Phosphothreonine.
 MOD_RES 292 292 Phosphothreonine.
 MOD_RES 294 294 Phosphoserine (By similarity).
 MOD_RES 301 301 Phosphoserine (By similarity).
 MOD_RES 304 304 Phosphothreonine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; RNA-binding; Spliceosome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 312 AA 
Protein Sequence
MSLKIQTSNV TNKNDPKSIN SRVFIGNLNT AVVKKSDVET IFSKYGRVAG CSVHKGYAFV 60
QYANERHARA AVLGENGRVL AGQTLDINMA GEPKPNRPKG LKRAATAIYS GYSFDYDYYQ 120
DYFCARLFDY RGRLSPVPVP RAVPVKRPRV TVPLVRRVKT TIPVKLFARS TAVTTGSAKI 180
KLKSSELQTI KTELTQIKSN IDALLGRLEQ IAEEQKANPD GKKKGDSSSG GGGGSSGGGG 240
SSNVGGGSSG GSGSCSSSSR LPAPQEDTAS EAGTPQGEVQ TRDDGDEEGL LTHSEEELEH 300
SQDTDAEDGA LQ 312 
Gene Ontology
 GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 
Interpro
 IPR017347; hnRNP_C_Raly.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS