UniProt Accession

 HCD2_HUMAN; Q99714; Q5H927; Q8TCV9; Q96HD5 

Genbank Protein ID

 U96132; U73514; AF069134; AF035555; AF037438; Z97054; CH471154; BC000372; BC008708; AY092415 

Genbank Nucleotide ID

 AAC51812.1; AAB68958.1; AAC39900.1; AAC15902.1; AAC16419.1; CAI42652.1; EAW93158.1; AAH00372.1; AAH08708.1; AAM18189.1 

Protein Name

 3-hydroxyacyl-CoA dehydrogenase type-2 

Protein Synonyms/Alias

 17-beta-hydroxysteroid dehydrogenase 10; 17-beta-HSD 10; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; Endoplasmic reticulum-associated amyloid beta-peptide-binding protein; Mitochondrial ribonuclease P protein 2; Mitochondrial RNase P protein 2; Short-chain type dehydrogenase/reductase XH98G2; Type II HADH 

Gene Name

 HSD17B10 

Gene Synonyms/Alias

 ERAB; HADH2; MRPP2; SCHAD; XH98G2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
52	SGGEAQAKKLGNNCV	ubiquitination	[1]
79	QTALALAKGKFGRVD	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). 

Sequence Annotation

 NP_BIND 12 41 NAD.
 ACT_SITE 168 168 Proton acceptor.
 BINDING 155 155 Substrate.
 BINDING 172 172 NAD.
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Chromosomal rearrangement; Complete proteome; Disease mutation; Mental retardation; Mitochondrion; NAD; Oxidoreductase; Reference proteome; tRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 261 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0005886; C:plasma membrane; TAS:ProtInc.
 GO:0047015; F:3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity; IEA:EC.
 GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; EXP:Reactome.
 GO:0008709; F:cholate 7-alpha-dehydrogenase activity; TAS:ProtInc.
 GO:0009083; P:branched-chain amino acid catabolic process; TAS:Reactome.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0006629; P:lipid metabolic process; TAS:ProtInc.
 GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.