UniProt Accession

 STRAP_HUMAN; Q9Y3F4; B2R5S5; Q5TZT4; Q9NTK0; Q9UQC8 

Genbank Protein ID

 AJ010025; AB024327; AF161496; AY049776; AL136691; BT020044; BT020045; AK312295; CH471094; BC000162; BC062306 

Genbank Nucleotide ID

 CAB38041.1; BAA75544.1; AAF29111.1; AAL15433.1; CAB66626.1; AAV38847.1; AAV38848.1; BAG35222.1; EAW96356.1; AAH00162.1; AAH62306.1 

Protein Name

 Serine-threonine kinase receptor-associated protein 

Protein Synonyms/Alias

 MAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WD 

Gene Name

 STRAP 

Gene Synonyms/Alias

 MAWD; UNRIP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
59	IGTFLGHKGAVWGAT	ubiquitination	[1, 2]
100	ELMTLAHKHIVKTVD	ubiquitination	[1]
122	LLTGGQDKLLRIYDL	ubiquitination	[2]
156	ALWCSEDKQILSADD	ubiquitination	[1]
249	GEDFKLYKYDYNSGE	ubiquitination	[2]
298	LWQTVVGKTYGLWKC	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. 

Sequence Annotation

 REPEAT 12 56 WD 1.
 REPEAT 57 96 WD 2.
 REPEAT 98 137 WD 3.
 REPEAT 141 179 WD 4.
 REPEAT 180 212 WD 5.
 REPEAT 221 262 WD 6.
 REPEAT 263 302 WD 7.
 MOD_RES 335 335 Phosphoserine.
 MOD_RES 338 338 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Spliceosome; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 350 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IDA:HPA.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; TAS:Reactome.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:Reactome. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00320; GPROTEINBRPT.