CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007469
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein BUD31 homolog 
Protein Synonyms/Alias
 Protein EDG-2; Protein G10 homolog 
Gene Name
 BUD31 
Gene Synonyms/Alias
 EDG2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
9PKVKRSRKAPPDGWEubiquitination[1]
28TLDELDQKMREAETEubiquitination[1, 2]
42EPHEGKRKVESLWPIubiquitination[3]
66YIFDLFYKRKAISREubiquitination[4]
125ICRVPKSKLEVGRIIacetylation[5]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861
Functional Description
  
Sequence Annotation
 MOTIF 2 10 Nuclear localization signal (Potential).
 MOD_RES 125 125 N6-acetyllysine.  
Keyword
 Acetylation; Complete proteome; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 144 AA 
Protein Sequence
MPKVKRSRKA PPDGWELIEP TLDELDQKMR EAETEPHEGK RKVESLWPIF RIHHQKTRYI 60
FDLFYKRKAI SRELYEYCIK EGYADKNLIA KWKKQGYENL CCLRCIQTRD TNFGTNCICR 120
VPKSKLEVGR IIECTHCGCR GCSG 144 
Gene Ontology
 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc. 
Interpro
 IPR018230; BUD31/G10-rel_CS.
 IPR001748; G10. 
Pfam
 PF01125; G10 
SMART
  
PROSITE
 PS00997; G10_1
 PS00998; G10_2 
PRINTS
 PR00322; G10.