| Tag | Content |
|---|
| CPLM ID | CPLM-015239 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DENN domain-containing protein 5A |
Protein Synonyms/Alias | Rab6-interacting protein 1; Rab6IP1 |
Gene Name | Dennd5a |
Gene Synonyms/Alias | Rab6ip1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 628 | LRTSMYQKCTTVDEA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). |
Sequence Annotation | DOMAIN 68 138 UDENN.
DOMAIN 202 390 DENN.
DOMAIN 512 588 dDENN.
DOMAIN 787 950 RUN 1.
DOMAIN 954 1062 PLAT.
DOMAIN 1134 1280 RUN 2.
MOD_RES 193 193 Phosphoserine (By similarity). |
Keyword | 3D-structure; Complete proteome; Golgi apparatus; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1287 AA |
Protein Sequence | MSGGGGGGGS APSRFADYFV ICGLDTETGL EPDELSALCQ YIQASKARDG ASPFISSTTE 60
GENFEQTPLR RTFKSKVLAR YPENVDWNPF DQDAVGMLCM PKGLAFKTQA DPREPQFHAF 120
IITREDGSRT FGFALTFYEE VTSKQICSAM QTLYHMHNAE YDVLHAPLAD GGDQSGMEDG 180
EGIPGTKLQR FNSYDISRDT LYVSKCICLI TPMSFMKACR SVLQQLHQAV TSPQPPPLPL 240
ESYIYNVLYE VPLPPPGRSL KFSGVYGPII CQRPSTNELP LFDFPVKEVF ELLGVENVFQ 300
LFTCALLEFQ ILLYSQHYQR LMTVAETITA LMFPFQWQHV YVPILPASLL HFLDAPVPYL 360
MGLHSNGLDD RSKLELPQEA NLCFVDVDNH FIELPEDLPQ FPNKLEFVQE VSEILMAFGV 420
PPEGNLHCSE SASKLKRIRA SELVSDKRNG NIAGSPLHSY ELLKENETIA RLQALVKRTG 480
VSLEKLEVRE DPSSNKDFKV QCDEEELRIY QLNIQIREVF ANRFTQMFAD YEVFVIQPSQ 540
DKESWFTNRE QMQNFDKASF LSDQPEPYLP FLSRFLETQM FASFIDNKIM CHDDDDKDPV 600
LRVFDSRVDK IRLLNVRTPT LRTSMYQKCT TVDEAEKAIE LRLAKIDHTA VHPHLLDMKI 660
GQGKYEPGFF PKLQSDVLCT GPASNKWTKR NAPAQWRRKD RQKQHTEHLR LDNDQREKYI 720
QEARNMGSTI RQPKLSNLSP SVIAQTNWKF VEGLLKECRN KTKRMLVEKM GREAVELGHG 780
EVNITGVEEN TLIASLCDLL ERIWSHGLQV KQGKSALWSH LLHYQENRQR KLTSGSLSTS 840
GILLDSERRK SDASAVMSPL RISLIQDMRH IQNIGEIKTD VGKARAWVRL SMEKKLLSRH 900
LKQLLSDHEL TKKLYKRYAF LRCDDEKEQF LYHLLSFNAV DYFCFTNVFT TILIPYHILI 960
VPSKKLGGSM FTANPWICIS GELGETQILQ IPRNVLEMTF ECQNLGKLTT VQIGHDNSGL 1020
YAKWLVECVM VRNEVTGHTY KFPCGRWLGK GMDDGSLERV LVGELLTSLP EVDERPCRTP 1080
PLQQSPSVIR RLVTISPNNK PKLNTGQIQE SIGEAVNGIV KHFHKPEKER GSLTLLLCGE 1140
CGLVSALEQA FQHGFKSPRL FKNVFIWDFL EKAQTYYETL EQNDVVPEEN WHTRARNFCR 1200
FVTAVNNTPR NIGKDGKFQM LVCLGARDHL LHHWIALLAD CPITAHMYED VALIKDHTLV 1260
NSLIRVLQTL QEFNITLDTS LVKGIDI 1287 |
Gene Ontology | GO:0005794; C:Golgi apparatus; IDA:UniProtKB. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; IBA:RefGenome. GO:0017137; F:Rab GTPase binding; IDA:MGI. GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |