UniProt Accession

 HIG1A_HUMAN; Q9Y241; Q9UFZ2 

Genbank Protein ID

 AF145385; AF077034; AL110233; CR457385; BC000601; BC009583; BC009594; BC070277; BG400624 

Genbank Nucleotide ID

 AAD33954.1; AAD27767.1; CAB53686.1; CAG33666.1; AAH00601.1; AAH09583.1; AAH09594.1; AAH70277.1 

Protein Name

 HIG1 domain family member 1A, mitochondrial 

Protein Synonyms/Alias

 Hypoxia-inducible gene 1 protein; RCF1 homolog A; RCF1a 

Gene Name

 HIGD1A 

Gene Synonyms/Alias

 HIG1; HSPC010 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
33	YEEDQGSKLIRKAKE	ubiquitination	[1, 2]
104	MYREFWAKPKP****	ubiquitination	[2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes. 

Sequence Annotation

 DOMAIN 1 93 HIG1.
 MOD_RES 2 2 N-acetylserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Respiratory chain; Stress response; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 93 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IDA:LIFEdb.
 GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 

Interpro

 IPR007667; Hypoxia_induced_domain. 

Pfam

 PF04588; HIG_1_N 

SMART

  

PROSITE

 PS51503; HIG1 

PRINTS