CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001173
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Large neutral amino acids transporter small subunit 3 
Protein Synonyms/Alias
 L-type amino acid transporter 3; Prostate cancer overexpressed gene 1 protein; Solute carrier family 43 member 1 
Gene Name
 SLC43A1 
Gene Synonyms/Alias
 LAT3; PB39; POV1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
264MGQRLSQKAPSLEDGubiquitination[1]
382YIMDWRIKDCVDAPTubiquitination[2]
404ARDGVATKSIRPRYCubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer. 
Sequence Annotation
 CARBOHYD 57 57 N-linked (GlcNAc...) (Potential).
 CARBOHYD 212 212 N-linked (GlcNAc...) (Potential).
 CARBOHYD 229 229 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Amino-acid transport; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 559 AA 
Protein Sequence
MAPTLQQAYR RRWWMACTAV LENLFFSAVL LGWGSLLIIL KNEGFYSSTC PAESSTNTTQ 60
DEQRRWPGCD QQDEMLNLGF TIGSFVLSAT TLPLGILMDR FGPRPVRLVG SACFTASCTL 120
MALASRDVEA LSPLIFLALS LNGFGGICLT FTSLTLPNMF GNLRSTLMAL MIGSYASSAI 180
TFPGIKLIYD AGVAFVVIMF TWSGLACLIF LNCTLNWPIE AFPAPEEVNY TKKIKLSGLA 240
LDHKVTGDLF YTHVTTMGQR LSQKAPSLED GSDAFMSPQD VRGTSENLPE RSVPLRKSLC 300
SPTFLWSLLT MGMTQLRIIF YMAAVNKMLE YLVTGGQEHE TNEQQQKVAE TVGFYSSVFG 360
AMQLLCLLTC PLIGYIMDWR IKDCVDAPTQ GTVLGDARDG VATKSIRPRY CKIQKLTNAI 420
SAFTLTNLLL VGFGITCLIN NLHLQFVTFV LHTIVRGFFH SACGSLYAAV FPSNHFGTLT 480
GLQSLISAVF ALLQQPLFMA MVGPLKGEPF WVNLGLLLFS LLGFLLPSYL FYYRARLQQE 540
YAANGMGPLK VLSGSEVTA 559 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:UniProtKB.
 GO:0015179; F:L-amino acid transmembrane transporter activity; IEA:Compara.
 GO:0015175; F:neutral amino acid transmembrane transporter activity; IDA:UniProtKB. 
Interpro
 IPR027199; LAT3.
 IPR011701; MFS.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR027192; SLC43. 
Pfam
 PF07690; MFS_1 
SMART
  
PROSITE
  
PRINTS