CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007626
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Excitatory amino acid transporter 2 
Protein Synonyms/Alias
 GLT-1; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2 
Gene Name
 Slc1a2 
Gene Synonyms/Alias
 Eaat2; Glt1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
12EGANNMPKQVEVRMHubiquitination[1]
557VTLAANGKSADCSVEubiquitination[1]
569SVEEEPWKREK****ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. 
Sequence Annotation
 MOD_RES 493 493 Phosphotyrosine.
 MOD_RES 537 537 Phosphotyrosine.
 MOD_RES 562 562 Phosphoserine.
 LIPID 38 38 S-palmitoyl cysteine.
 CARBOHYD 205 205 N-linked (GlcNAc...) (Potential).
 CARBOHYD 215 215 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Direct protein sequencing; Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 572 AA 
Protein Sequence
MASTEGANNM PKQVEVRMHD SHLSSDEPKH RNLGMRMCDK LGKNLLLSLT VFGVILGAVC 60
GGLLRLASPI HPDVVMLIAF PGDILMRMLK MLILPLIISS LITGLSGLDA KASGRLGTRA 120
MVYYMSTTII AAVLGVILVL AIHPGNPKLK KQLGPGKKND EVSSLDAFLD LIRNLFPENL 180
VQACFQQIQT VTKKVLVAPP SEEANTTKAV ISMLNETMNE APEETKIVIK KGLEFKDGMN 240
VLGLIGFFIA FGIAMGKMGE QAKLMVEFFN ILNEIVMKLV IMIMWYSPLG IACLICGKII 300
AIKDLEVVAR QLGMYMITVI VGLIIHGGIF LPLIYFVVTR KNPFSFFAGI FQAWITALGT 360
ASSAGTLPVT FRCLEDNLGI DKRVTRFVLP VGATINMDGT ALYEAVAAIF IAQMNGVILD 420
GGQIVTVSLT ATLASIGAAS IPSAGLVTML LILTAVGLPT EDISLLVAVD WLLDRMRTSV 480
NVVGDSFGAG IVYHLSKSEL DTIDSQHRMQ EDIEMTKTQS IYDDKNHRES NSNQCVYAAH 540
NSVVIDECKV TLAANGKSAD CSVEEEPWKR EK 572 
Gene Ontology
 GO:0030673; C:axolemma; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; IC:MGI.
 GO:0015501; F:glutamate:sodium symporter activity; IDA:MGI.
 GO:0017153; F:sodium:dicarboxylate symporter activity; IEA:InterPro.
 GO:0030534; P:adult behavior; IMP:MGI.
 GO:0031668; P:cellular response to extracellular stimulus; IMP:MGI.
 GO:0070779; P:D-aspartate import; IEA:Compara.
 GO:0051938; P:L-glutamate import; IEA:Compara.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0010259; P:multicellular organismal aging; IMP:MGI.
 GO:0046326; P:positive regulation of glucose import; IMP:MGI.
 GO:0043200; P:response to amino acid stimulus; IMP:MGI.
 GO:0042493; P:response to drug; IMP:MGI.
 GO:0009611; P:response to wounding; IMP:MGI.
 GO:0021537; P:telencephalon development; IMP:MGI.
 GO:0007632; P:visual behavior; IMP:MGI. 
Interpro
 IPR001991; Na-dicarboxylate_symporter.
 IPR018107; Na-dicarboxylate_symporter_CS. 
Pfam
 PF00375; SDF 
SMART
  
PROSITE
 PS00713; NA_DICARBOXYL_SYMP_1
 PS00714; NA_DICARBOXYL_SYMP_2 
PRINTS
 PR00173; EDTRNSPORT.