UniProt Accession

 D3Z6F5_MOUSE; D3Z6F5 

Genbank Protein ID

 AC162291; CH466528 

Genbank Nucleotide ID

 EDL09448.1 

Protein Name

 ATP synthase subunit alpha 

Protein Synonyms/Alias

  

Gene Name

 Atp5a1 

Gene Synonyms/Alias

 mCG_18273 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
73	VVVFGNDKLIKEGDV	acetylation	[1, 2, 3]
73	VVVFGNDKLIKEGDV	ubiquitination	[4]
76	FGNDKLIKEGDVVKR	acetylation	[1, 2, 3]
82	IKEGDVVKRTGAIVD	acetylation	[2, 3]
111	LGNAIDGKGPIGSKT	acetylation	[1, 2, 3, 5]
111	LGNAIDGKGPIGSKT	succinylation	[5]
111	LGNAIDGKGPIGSKT	ubiquitination	[4]
117	GKGPIGSKTRRRVGL	acetylation	[2, 5]
117	GKGPIGSKTRRRVGL	succinylation	[5]
117	GKGPIGSKTRRRVGL	ubiquitination	[4]
125	TRRRVGLKAPGIIPR	ubiquitination	[4]
144	EPMQTGIKAVDSLVP	acetylation	[6]
144	EPMQTGIKAVDSLVP	ubiquitination	[4]
168	IGDRQTGKTSIAIDT	ubiquitination	[4]
180	IDTIINQKRFNDGTD	acetylation	[2, 3, 5]
180	IDTIINQKRFNDGTD	succinylation	[5]
180	IDTIINQKRFNDGTD	ubiquitination	[4]
189	FNDGTDEKKKLYCIY	acetylation	[1, 2, 3, 5, 7, 8]
189	FNDGTDEKKKLYCIY	succinylation	[5]
190	NDGTDEKKKLYCIYV	acetylation	[1, 2]
191	DGTDEKKKLYCIYVA	acetylation	[1, 2]
211	STVAQLVKRLTDADA	acetylation	[1, 2, 3, 5, 6]
211	STVAQLVKRLTDADA	succinylation	[5]
211	STVAQLVKRLTDADA	ubiquitination	[4]
220	LTDADAMKYTIVVSA	acetylation	[3]
255	EYFRDNGKHALIIYD	acetylation	[1, 2, 3, 5]
255	EYFRDNGKHALIIYD	succinylation	[5]
255	EYFRDNGKHALIIYD	ubiquitination	[4]
266	IIYDDLSKQAVAYRQ	acetylation	[3]
377	AAQTRAMKQVAGTMK	acetylation	[1, 2, 3, 5]
377	AAQTRAMKQVAGTMK	succinylation	[5]
377	AAQTRAMKQVAGTMK	ubiquitination	[4]
384	KQVAGTMKLELAQYR	acetylation	[1, 2, 3, 6]
384	KQVAGTMKLELAQYR	ubiquitination	[4]
422	VRLTELLKQGQYSPM	acetylation	[3]
448	GVRGYLDKLEPSKIT	acetylation	[1, 2, 3, 5, 6, 7, 8, 9]
448	GVRGYLDKLEPSKIT	succinylation	[5]
448	GVRGYLDKLEPSKIT	ubiquitination	[4]
453	LDKLEPSKITKFENA	acetylation	[2, 3]
453	LDKLEPSKITKFENA	ubiquitination	[4]
456	LEPSKITKFENAFLS	acetylation	[2, 3, 5, 8]
456	LEPSKITKFENAFLS	succinylation	[5]
481	GNIRSDGKISEQSDA	acetylation	[1, 2, 3, 5, 7, 8]
481	GNIRSDGKISEQSDA	succinylation	[5]
489	ISEQSDAKLKEIVTN	acetylation	[1, 2, 3, 5, 7, 8, 9]
489	ISEQSDAKLKEIVTN	succinylation	[5]
489	ISEQSDAKLKEIVTN	succinylation	[5]
489	ISEQSDAKLKEIVTN	ubiquitination	[4]
491	EQSDAKLKEIVTNFL	acetylation	[1, 2, 3, 6, 7, 10]

Reference

 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [6] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [7] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199]
 [8] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]
 [9] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [10] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 

Functional Description

 Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity). 

Sequence Annotation

  

Keyword

 ATP synthesis; ATP-binding; CF(1); Complete proteome; Hydrogen ion transport; Ion transport; Nucleotide-binding; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 503 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005753; C:mitochondrial proton-transporting ATP synthase complex; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0045261; C:proton-transporting ATP synthase complex, catalytic core F(1); IEA:UniProtKB-KW.
 GO:0008180; C:signalosome; IEA:Compara.
 GO:0005524; F:ATP binding; IMP:MGI.
 GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IMP:MGI.
 GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
 GO:0015986; P:ATP synthesis coupled proton transport; IEA:InterPro.
 GO:0009790; P:embryo development; IMP:MGI.
 GO:0006629; P:lipid metabolic process; IMP:MGI.
 GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Compara. 

Interpro

 IPR020003; ATPase_a/bsu_AS.
 IPR004100; ATPase_a/bsu_N.
 IPR005294; ATPase_F1-cplx_asu.
 IPR023366; ATPase_F1/A1-cplx_a_su_N.
 IPR000793; ATPase_F1/V1/A1-cplx_a/bsu_C.
 IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00006; ATP-synt_ab
 PF00306; ATP-synt_ab_C
 PF02874; ATP-synt_ab_N 

SMART

  

PROSITE

 PS00152; ATPASE_ALPHA_BETA 

PRINTS