UniProt Accession

 RUVB2_DROME; Q9V3K3 

Genbank Protein ID

 AF233279; AE014296; AY060952; AY061155 

Genbank Nucleotide ID

 AAF43412.1; AAF49182.1; AAL28500.1; AAL28703.1 

Protein Name

 RuvB-like helicase 2 

Protein Synonyms/Alias

 Dreptin; Drep; Reptin 

Gene Name

 rept 

Gene Synonyms/Alias

 CG9750 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
180	KIIECFMKEKIQAGD	acetylation	[1]
361	RTVPYSEKEVKEILK	acetylation	[1]
423	EVNTEDVKKVYSLFL	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth. 

Sequence Annotation

 NP_BIND 73 80 ATP (By similarity).  

Keyword

 ATP-binding; Chromatin regulator; Complete proteome; DNA damage; DNA repair; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 481 AA 

Protein Sequence

Gene Ontology

 GO:0031011; C:Ino80 complex; IDA:UniProtKB.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0035267; C:NuA4 histone acetyltransferase complex; IDA:UniProtKB.
 GO:0035102; C:PRC1 complex; IDA:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0043141; F:ATP-dependent 5'-3' DNA helicase activity; IEA:InterPro.
 GO:0003714; F:transcription corepressor activity; IMP:UniProtKB.
 GO:0006342; P:chromatin silencing; IMP:FlyBase.
 GO:0032508; P:DNA duplex unwinding; IEA:GOC.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0016573; P:histone acetylation; IDA:UniProtKB.
 GO:0043486; P:histone exchange; IDA:UniProtKB.
 GO:0007095; P:mitotic G2 DNA damage checkpoint; IGI:FlyBase.
 GO:0022008; P:neurogenesis; IMP:FlyBase.
 GO:0042127; P:regulation of cell proliferation; IMP:UniProtKB.
 GO:0030111; P:regulation of Wnt receptor signaling pathway; IMP:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR012340; NA-bd_OB-fold.
 IPR027417; P-loop_NTPase.
 IPR027238; RuvB-like.
 IPR010339; TIP49_C. 

Pfam

 PF06068; TIP49 

SMART

 SM00382; AAA 

PROSITE

  

PRINTS