CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013371
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat-containing protein 8A 
Protein Synonyms/Alias
  
Gene Name
 Lrrc8a 
Gene Synonyms/Alias
 Lrrc8 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
501NLRALHIKFTDIKEIacetylation[1]
622NLQEIDLKDNNLKTIacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Involved in B-cell development (By similarity). Required for the pro-B cell to pre-B cell transition (By similarity). 
Sequence Annotation
 REPEAT 373 401 LRR 1.
 REPEAT 402 424 LRR 2.
 REPEAT 425 447 LRR 3.
 REPEAT 448 470 LRR 4.
 REPEAT 471 494 LRR 5.
 REPEAT 495 518 LRR 6.
 REPEAT 519 545 LRR 7.
 REPEAT 546 568 LRR 8.
 REPEAT 569 592 LRR 9.
 REPEAT 593 615 LRR 10.
 REPEAT 616 640 LRR 11.
 REPEAT 641 663 LRR 12.
 REPEAT 664 686 LRR 13.
 REPEAT 687 706 LRR 14.
 REPEAT 707 732 LRR 15.
 REPEAT 733 755 LRR 16.
 REPEAT 756 777 LRR 17.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 217 217 Phosphoserine (By similarity).
 CARBOHYD 83 83 N-linked (GlcNAc...) (Potential).
 CARBOHYD 191 191 N-linked (GlcNAc...) (Potential).
 CARBOHYD 526 526 N-linked (GlcNAc...) (Potential).
 CARBOHYD 554 554 N-linked (GlcNAc...) (Potential).
 CARBOHYD 592 592 N-linked (GlcNAc...) (Potential).
 CARBOHYD 660 660 N-linked (GlcNAc...) (Potential).
 CARBOHYD 696 696 N-linked (GlcNAc...) (Potential).
 CARBOHYD 755 755 N-linked (GlcNAc...) (Potential).  
Keyword
 Acetylation; Complete proteome; Differentiation; Glycoprotein; Leucine-rich repeat; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 810 AA 
Protein Sequence
MIPVTELRYF ADTQPAYRIL KPWWDVFTDY ISIVMLMIAV FGGTLQVTQD KMICLPCKWV 60
TKDSCNDSFR GWGASSPEPT YPNSTVLPTP DTGPTGIKYD LDRHQYNYVD AVCYENRLHW 120
FAKYFPYLVL LHTLIFLACS NFWFKFPRTS SKLEHFVSIL LKCFDSPWTT RALSETVVEE 180
SDPKPAFSKM NGSMDKKSST VSEDVEATVP MLQRTKSRIE QGIVDRSETG VLDKKEGEQA 240
KALFEKVKKF RTHVEEGDIV YRLYMRQTII KVIKFFLIIC YTVYYVHNIK FDVDCTVDIE 300
SLTGYRTYRC AHPLATLFKI LASFYISLVI FYGLICMYTL WWMLRRSLKK YSFESIREES 360
SYSDIPDVKN DFAFMLHLID QYDPLYSKRF AVFLSEVSEN KLRQLNLNNE WTLDKLRQRL 420
TKNAQDKLEL HLFMLSGIPD TVFDLLELEV LKLELIPDVT IPPSIAQLTG LKELWLYHTA 480
AKIEAPALAF LRENLRALHI KFTDIKEIPL WIYSLKTLEE LHLTGNLSAE NNRYIVIDGL 540
RELKRLKVLR LKSNLSKLPQ VVTDVGVHLQ KLSINNEGTK LIVLNSLKKM VNLTELELIR 600
CDLERIPHSI FSLHNLQEID LKDNNLKTIE EIISFQHLHR LTCLKLWYNH IAYIPIQIGN 660
LTNLERLYLN RNKIEKIPTQ LFYCRKLRYL DLSHNNLTLL PADIGLLQNL QNLAVTANRI 720
EALPPELFQC RKLRALHLGN NVLQSLPSRV GELTNLTQIE LRGNRLECLP VELGECPLLK 780
RSGLVVEEDL FSTLPPEVKE RLWRADKEQA 810 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0002329; P:pre-B cell differentiation; ISS:UniProtKB. 
Interpro
 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR021040; LRR_protein-8_N. 
Pfam
 PF12534; DUF3733
 PF12799; LRR_4 
SMART
 SM00369; LRR_TYP 
PROSITE
 PS51450; LRR 
PRINTS