| Tag | Content |
|---|
| CPLM ID | CPLM-016116 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pantothenate kinase 4 |
Protein Synonyms/Alias | mPanK4; Pantothenic acid kinase 4 |
Gene Name | Pank4 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 137 | FKDLIEEKLRLKVDK | ubiquitination | [1] | | 171 | HEAFMYQKDSDPEFR | ubiquitination | [1] | | 234 | ALLTKTKKFDELLQL | ubiquitination | [1] | | 487 | FRQKYWGKLQTLRHQ | ubiquitination | [1] | | 590 | QFGFEEAKRKLQERP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity). |
Sequence Annotation | BINDING 196 196 Acetyl-CoA (By similarity).
BINDING 199 199 Acetyl-CoA (By similarity).
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 320 320 Nitrated tyrosine. |
Keyword | Acetylation; Alternative splicing; ATP-binding; Coenzyme A biosynthesis; Complete proteome; Cytoplasm; Kinase; Nitration; Nucleotide-binding; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 820 AA |
Protein Sequence | MAERGASGGG SGGDSLDKSI TLPPDEIFRN LENAKRFAID IGGSLTKLAY YSTVQHKVAK 60
VRSFDHPGKD VEQDHEPPYE ISVQEEITAR LHFIKFENTY MEACLDFIRD HLVNTETKVI 120
QATGGGAYKF KDLIEEKLRL KVDKEDVMTC LIKGCNFVLK NIPHEAFMYQ KDSDPEFRFQ 180
TNHPNIFPYL LVNIGSGVSI VKVETEDRFE WIGGSSIGGG TFWGLGALLT KTKKFDELLQ 240
LASRGRHANV DMLVQDIYGG AHQTLGLSGN LIASSFGKSA TADREFSKED MAKSLLHMIS 300
NDIGQLACLY AKLHGLDRVY FGGFFIRGHP VTMRTITYSI NFFSKGEVQA LFLRHEGYLG 360
AIGAFLKGAE QDNPNQYSWG ENYAASSGLM STSPELCPTQ RARSGTFDLL EMDRLERPLV 420
NLPLLLDPSS YVPDTVDLTD DALARQYWLT CFEEALDGVV KRAVASQPES MDAVERAEKF 480
RQKYWGKLQT LRHQPFAYGT LTVRSLLDTR EHCLNEFNFP DPYSKVKQKE NGLALKCFQS 540
VTRSLDSLGW EERQLALVKG LLAGNVFDWG AKAVSDVLES DPQFGFEEAK RKLQERPWLV 600
DSYTKWLQRL KGPPHKCALI FADNSGIDII LGVFPFVREL LFRGTEVILA CNSGPALNDV 660
TYSESLIVAE RIAAMDPIIC TALREDRLLL VQTGSSSPCL DLSLCTSRTT TCMVLPFAMW 720
VLWTKLKSLV EKCLSPLSIL LACSVLSAKS RLDKGLAVLV RERGADLVVI EGMGRAIHTN 780
YHALLRCESL KLAVVKNAWL AERLGGQLFS VIFKYEVPTK 820 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004594; F:pantothenate kinase activity; IEA:EC. GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |