CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003833
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Retinol-binding protein 3 
Protein Synonyms/Alias
 Interphotoreceptor retinoid-binding protein; IRBP; Interstitial retinol-binding protein 
Gene Name
 RBP3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1070LVEHIWKKIMHTDAMmethylation[1]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
 IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. 
Sequence Annotation
 REPEAT 18 320 1.
 REPEAT 321 630 2.
 REPEAT 631 931 3.
 REPEAT 932 1230 4.
 REGION 18 1230 4 X approximate tandem repeats.
 CARBOHYD 205 205 N-linked (GlcNAc...) (Potential).
 CARBOHYD 515 515 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Direct protein sequencing; Extracellular matrix; Glycoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Transport; Vitamin A. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1247 AA 
Protein Sequence
MMREWVLLMS VLLCGLAGPT HLFQPSLVLD MAKVLLDNYC FPENLLGMQE AIQQAIKSHE 60
ILSISDPQTL ASVLTAGVQS SLNDPRLVIS YEPSTPEPPP QVPALTSLSE EELLAWLQRG 120
LRHEVLEGNV GYLRVDSVPG QEVLSMMGEF LVAHVWGNLM GTSALVLDLR HCTGGQVSGI 180
PYIISYLHPG NTILHVDTIY NRPSNTTTEI WTLPQVLGER YGADKDVVVL TSSQTRGVAE 240
DIAHILKQMR RAIVVGERTG GGALDLRKLR IGESDFFFTV PVSRSLGPLG GGSQTWEGSG 300
VLPCVGTPAE QALEKALAIL TLRSALPGVV HCLQEVLKDY YTLVDRVPTL LQHLASMDFS 360
TVVSEEDLVT KLNAGLQAAS EDPRLLVRAI GPTETPSWPA PDAAAEDSPG VAPELPEDEA 420
IRQALVDSVF QVSVLPGNVG YLRFDSFADA SVLGVLAPYV LRQVWEPLQD TEHLIMDLRH 480
NPGGPSSAVP LLLSYFQGPE AGPVHLFTTY DRRTNITQEH FSHMELPGPR YSTQRGVYLL 540
TSHRTATAAE EFAFLMQSLG WATLVGEITA GNLLHTRTVP LLDTPEGSLA LTVPVLTFID 600
NHGEAWLGGG VVPDAIVLAE EALDKAQEVL EFHQSLGALV EGTGHLLEAH YARPEVVGQT 660
SALLRAKLAQ GAYRTAVDLE SLASQLTADL QEVSGDHRLL VFHSPGELVV EEAPPPPPAV 720
PSPEELTYLI EALFKTEVLP GQLGYLRFDA MAELETVKAV GPQLVRLVWQ QLVDTAALVI 780
DLRYNPGSYS TAIPLLCSYF FEAEPRQHLY SVFDRATSKV TEVWTLPQVA GQRYGSHKDL 840
YILMSHTSGS AAEAFAHTMQ DLQRATVIGE PTAGGALSVG IYQVGSSPLY ASMPTQMAMS 900
ATTGKAWDLA GVEPDITVPM SEALSIAQDI VALRAKVPTV LQTAGKLVAD NYASAELGAK 960
MATKLSGLQS RYSRVTSEVA LAEILGADLQ MLSGDPHLKA AHIPENAKDR IPGIVPMQIP 1020
SPEVFEELIK FSFHTNVLED NIGYLRFDMF GDGELLTQVS RLLVEHIWKK IMHTDAMIID 1080
MRFNIGGPTS SIPILCSYFF DEGPPVLLDK IYSRPDDSVS ELWTHAQVVG ERYGSKKSMV 1140
ILTSSVTAGT AEEFTYIMKR LGRALVIGEV TSGGCQPPQT YHVDDTNLYL TIPTARSVGA 1200
SDGSSWEGVG VTPHVVVPAE EALARAKEML QHNQLRVKRS PGLQDHL 1247 
Gene Ontology
 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0033165; C:interphotoreceptor matrix; IEA:UniProtKB-SubCell.
 GO:0016918; F:retinal binding; IEA:UniProtKB-KW.
 GO:0005501; F:retinoid binding; TAS:ProtInc.
 GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0006508; P:proteolysis; IEA:InterPro.
 GO:0001523; P:retinoid metabolic process; TAS:Reactome.
 GO:0006810; P:transport; IEA:UniProtKB-KW.
 GO:0007601; P:visual perception; TAS:ProtInc. 
Interpro
 IPR024591; Interphotorcpt_retinol-bd_N.
 IPR005151; Interphotoreceptor_retinol-bd. 
Pfam
 PF11918; DUF3436
 PF03572; Peptidase_S41 
SMART
 SM00245; TSPc 
PROSITE
  
PRINTS