CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008953
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tyrosine-protein kinase receptor TYRO3 
Protein Synonyms/Alias
 Etk2/tyro3; TK19-2; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase TIF 
Gene Name
 Tyro3 
Gene Synonyms/Alias
 Dtk; Rse; Tif 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
497ISDELKEKLEDVLIPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. 
Sequence Annotation
 DOMAIN 31 118 Ig-like C2-type 1.
 DOMAIN 129 209 Ig-like C2-type 2.
 DOMAIN 214 307 Fibronectin type-III 1.
 DOMAIN 312 403 Fibronectin type-III 2.
 DOMAIN 508 785 Protein kinase.
 NP_BIND 514 522 ATP (By similarity).
 ACT_SITE 645 645 Proton acceptor (By similarity).
 BINDING 540 540 ATP (By similarity).
 MOD_RES 671 671 Phosphotyrosine; by autocatalysis (By
 MOD_RES 675 675 Phosphotyrosine; by autocatalysis (By
 MOD_RES 676 676 Phosphotyrosine; by autocatalysis (By
 MOD_RES 794 794 Phosphotyrosine; by autocatalysis (By
 CARBOHYD 53 53 N-linked (GlcNAc...) (Potential).
 CARBOHYD 75 75 N-linked (GlcNAc...) (Potential).
 CARBOHYD 181 181 N-linked (GlcNAc...).
 CARBOHYD 220 220 N-linked (GlcNAc...) (Potential).
 CARBOHYD 230 230 N-linked (GlcNAc...) (Potential).
 CARBOHYD 283 283 N-linked (GlcNAc...) (Potential).
 CARBOHYD 356 356 N-linked (GlcNAc...) (Potential).
 CARBOHYD 370 370 N-linked (GlcNAc...) (Potential).
 DISULFID 54 107 By similarity.
 DISULFID 150 193 By similarity.  
Keyword
 3D-structure; Alternative splicing; ATP-binding; Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 880 AA 
Protein Sequence
MALRRSMGWP GLRPLLLAGL ASLLLPGSAA AGLKLMGAPV KMTVSQGQPV KLNCSVEGME 60
DPDIHWMKDG TVVQNASQVS ISISEHSWIG LLSLKSVERS DAGLYWCQVK DGEETKISQS 120
VWLTVEGVPF FTVEPKDLAV PPNAPFQLSC EAVGPPEPVT IYWWRGLTKV GGPAPSPSVL 180
NVTGVTQRTE FSCEARNIKG LATSRPAIVR LQAPPAAPFN TTVTTISSYN ASVAWVPGAD 240
GLALLHSCTV QVAHAPGEWE ALAVVVPVPP FTCLLRNLAP ATNYSLRVRC ANALGPSPYG 300
DWVPFQTKGL APARAPQNFH AIRTDSGLIL EWEEVIPEDP GEGPLGPYKL SWVQENGTQD 360
ELMVEGTRAN LTDWDPQKDL ILRVCASNAI GDGPWSQPLV VSSHDHAGRQ GPPHSRTSWV 420
PVVLGVLTAL ITAAALALIL LRKRRKETRF GQAFDSVMAR GEPAVHFRAA RSFNRERPER 480
IEATLDSLGI SDELKEKLED VLIPEQQFTL GRMLGKGEFG SVREAQLKQE DGSFVKVAVK 540
MLKADIIASS DIEEFLREAA CMKEFDHPHV AKLVGVSLRS RAKGRLPIPM VILPFMKHGD 600
LHAFLLASRI GENPFNLPLQ TLVRFMVDIA CGMEYLSSRN FIHRDLAARN CMLAEDMTVC 660
VADFGLSRKI YSGDYYRQGC ASKLPVKWLA LESLADNLYT VHSDVWAFGV TMWEIMTRGQ 720
TPYAGIENAE IYNYLIGGNR LKQPPECMEE VYDLMYQCWS ADPKQRPSFT CLRMELENIL 780
GHLSVLSTSQ DPLYINIERA EQPTESGSPE VHCGERSSSE AGDGSGVGAV GGIPSDSRYI 840
FSPGGLSESP GQLEQQPESP LNENQRLLLL QQGLLPHSSC 880 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005635; C:nuclear envelope; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0043548; F:phosphatidylinositol 3-kinase binding; ISS:UniProtKB.
 GO:0004713; F:protein tyrosine kinase activity; ISS:UniProtKB.
 GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:EC.
 GO:0043277; P:apoptotic cell clearance; IGI:UniProtKB.
 GO:0021885; P:forebrain cell migration; IGI:MGI.
 GO:0001779; P:natural killer cell differentiation; IGI:MGI.
 GO:0050728; P:negative regulation of inflammatory response; IGI:UniProtKB.
 GO:0045824; P:negative regulation of innate immune response; IGI:UniProtKB.
 GO:0051250; P:negative regulation of lymphocyte activation; IGI:MGI.
 GO:0043524; P:negative regulation of neuron apoptotic process; IGI:MGI.
 GO:0034122; P:negative regulation of toll-like receptor signaling pathway; IGI:UniProtKB.
 GO:0070050; P:neuron homeostasis; IMP:UniProtKB.
 GO:0042698; P:ovulation cycle; IGI:MGI.
 GO:0070527; P:platelet aggregation; IMP:UniProtKB.
 GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.
 GO:0043491; P:protein kinase B signaling cascade; IMP:UniProtKB.
 GO:0032940; P:secretion by cell; IMP:MGI.
 GO:0007283; P:spermatogenesis; IGI:UniProtKB.
 GO:0034446; P:substrate adhesion-dependent cell spreading; IMP:MGI.
 GO:0060068; P:vagina development; IGI:MGI. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom. 
Pfam
 PF00041; fn3
 PF07679; I-set
 PF07714; Pkinase_Tyr 
SMART
 SM00060; FN3
 SM00409; IG
 SM00408; IGc2
 SM00219; TyrKc 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR00109; TYRKINASE.