UniProt Accession

 IDHP_RAT; P56574; Q6DGF1 

Genbank Protein ID

 BC076398 

Genbank Nucleotide ID

 AAH76398.1 

Protein Name

 Isocitrate dehydrogenase [NADP], mitochondrial 

Protein Synonyms/Alias

 IDH; ICD-M; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase 

Gene Name

 Idh2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
45	HYAEKRIKVEKPVVE	acetylation	[1]
48	EKRIKVEKPVVEMDG	acetylation	[1]
67	RIIWQFIKEKLILPH	acetylation	[1]
69	IWQFIKEKLILPHVD	acetylation	[1]
80	PHVDVQLKYFDLGLP	acetylation	[1]
106	DSALATQKYSVAVKC	acetylation	[1]
129	RVEEFKLKKMWKSPN	acetylation	[1]
130	VEEFKLKKMWKSPNG	acetylation	[1]
155	FREPIICKNIPRLVP	acetylation	[1]
166	RLVPGWTKPITIGRH	acetylation	[1]
180	HAHGDQYKATDFVVD	acetylation	[1]
193	VDRAGMFKLVFTPKD	acetylation	[1]
199	FKLVFTPKDGSGAKE	acetylation	[1]
243	FQYSIQKKWPLYLST	acetylation	[1]
251	WPLYLSTKNTIMKAY	acetylation	[1]
256	STKNTIMKAYDGRFK	acetylation	[1]
263	KAYDGRFKDIFQEIF	acetylation	[1]
272	IFQEIFDKHYKTDFD	acetylation	[1]
275	EIFDKHYKTDFDKNK	acetylation	[1]
280	HYKTDFDKNKIWYEH	acetylation	[1]
282	KTDFDKNKIWYEHRL	acetylation	[1]
384	RGLEHRGKLDGNQDL	acetylation	[1]
400	RFAQTLEKVCVQTVE	acetylation	[1]
413	VESGAMTKDLAGCIH	acetylation	[1]
442	TDFLDTIKSNLDRAL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex (By similarity). 

Sequence Annotation

 NP_BIND 115 117 NADP (By similarity).
 NP_BIND 349 354 NADP (By similarity).
 REGION 134 140 Substrate binding (By similarity).
 METAL 291 291 Magnesium or manganese (By similarity).
 METAL 314 314 Magnesium or manganese (By similarity).
 BINDING 117 117 Substrate (By similarity).
 BINDING 122 122 NADP (By similarity).
 BINDING 149 149 Substrate (By similarity).
 BINDING 172 172 Substrate (By similarity).
 BINDING 299 299 NADP (By similarity).
 BINDING 367 367 NADP; via amide nitrogen and carbonyl
 MOD_RES 67 67 N6-acetyllysine (By similarity).
 MOD_RES 106 106 N6-acetyllysine (By similarity).
 MOD_RES 155 155 N6-acetyllysine (By similarity).
 MOD_RES 166 166 N6-acetyllysine (By similarity).
 MOD_RES 180 180 N6-acetyllysine (By similarity).
 MOD_RES 256 256 N6-acetyllysine (By similarity).
 MOD_RES 263 263 N6-acetyllysine (By similarity).
 MOD_RES 272 272 N6-acetyllysine (By similarity).
 MOD_RES 275 275 N6-acetyllysine (By similarity).
 MOD_RES 282 282 N6-acetyllysine (By similarity).
 MOD_RES 442 442 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; Mitochondrion; NADP; Oxidoreductase; Reference proteome; Transit peptide; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 452 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.
 GO:0000287; F:magnesium ion binding; ISS:UniProtKB.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.
 GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.
 GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 

Interpro

 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR004790; Isocitrate_DH_NADP.
 IPR024084; IsoPropMal-DH-like_dom. 

Pfam

 PF00180; Iso_dh 

SMART

  

PROSITE

 PS00470; IDH_IMDH 

PRINTS