CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041384
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 DNA-(apurinic or apyrimidinic site) lyase 
Protein Synonyms/Alias
  
Gene Name
 APEX1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
15KSKTAAKKNDKEAAGacetylation[1]
68KKGLDWVKEEAPDILubiquitination[2]
108YWSAPSDKEGYSGVGacetylation[3]
108YWSAPSDKEGYSGVGubiquitination[4]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 172 AA 
Protein Sequence
MYEPEAKKSK TAAKKNDKEA AGEGPALYED PPDQKTSPSG KPATLKICSW NVDGLRAWIK 60
KKGLDWVKEE APDILCLQET KCSENKLPAE LQELPGLSHQ YWSAPSDKEG YSGVGLLSRQ 120
CPLKVSYGIG DEEHDQEGRV IVAEFDSFVL VTAYVPNAGR GLVRLEYRQR WD 172 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004519; F:endonuclease activity; IEA:InterPro.
 GO:0006281; P:DNA repair; IEA:InterPro.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC. 
Interpro
 IPR020847; AP_endonuclease_F1_BS.
 IPR005135; Endo/exonuclease/phosphatase.
 IPR004808; ExoDNase_III. 
Pfam
 PF03372; Exo_endo_phos 
SMART
  
PROSITE
 PS00726; AP_NUCLEASE_F1_1
 PS51435; AP_NUCLEASE_F1_4 
PRINTS