CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018918
UniProt Accession
Genbank Protein ID
 X97261 
Genbank Nucleotide ID
Protein Name
 Metallothionein-1L 
Protein Synonyms/Alias
 MT-1L; Metallothionein-IL; MT-IL 
Gene Name
 MT1L 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
20CSCASSCKCKECKCTubiquitination[1]
22CASSCKCKECKCTSCubiquitination[1]
31CKCTSCKKSCCSCCPubiquitination[1]
43CCPMGCAKCAQGCVCubiquitination[1]
51CAQGCVCKGASEKCSubiquitination[2]
56VCKGASEKCSCCA**ubiquitination[2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity). 
Sequence Annotation
 REGION 1 29 Beta.
 REGION 30 61 Alpha.
 METAL 5 5 Divalent metal cation; cluster B.
 METAL 7 7 Divalent metal cation; cluster B.
 METAL 13 13 Divalent metal cation; cluster B.
 METAL 15 15 Divalent metal cation; cluster B.
 METAL 19 19 Divalent metal cation; cluster B.
 METAL 21 21 Divalent metal cation; cluster B.
 METAL 24 24 Divalent metal cation; cluster B.
 METAL 26 26 Divalent metal cation; cluster B.
 METAL 29 29 Divalent metal cation; cluster B.
 METAL 33 33 Divalent metal cation; cluster A.
 METAL 34 34 Divalent metal cation; cluster A.
 METAL 36 36 Divalent metal cation; cluster A.
 METAL 37 37 Divalent metal cation; cluster A.
 METAL 41 41 Divalent metal cation; cluster A.
 METAL 44 44 Divalent metal cation; cluster A.
 METAL 48 48 Divalent metal cation; cluster A.
 METAL 50 50 Divalent metal cation; cluster A.
 METAL 57 57 Divalent metal cation; cluster A.
 METAL 59 59 Divalent metal cation; cluster A.
 METAL 60 60 Divalent metal cation; cluster A.
 MOD_RES 1 1 N-acetylmethionine (By similarity).  
Keyword
 Acetylation; Cadmium; Complete proteome; Copper; Metal-binding; Metal-thiolate cluster; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 61 AA 
Protein Sequence
MDPNCSCATG GSCSCASSCK CKECKCTSCK KSCCSCCPMG CAKCAQGCVC KGASEKCSCC 60
A 61 
Gene Ontology
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
 GO:0046870; F:cadmium ion binding; NAS:UniProtKB.
 GO:0005507; F:copper ion binding; NAS:UniProtKB.
 GO:0008270; F:zinc ion binding; ISS:UniProtKB.
 GO:0071294; P:cellular response to zinc ion; IEP:UniProtKB.
 GO:0045926; P:negative regulation of growth; ISS:UniProtKB. 
Interpro
 IPR017854; Metalthion_dom.
 IPR023587; Metalthion_dom_vert.
 IPR003019; Metalthion_sfam_euk.
 IPR000006; Metalthion_vert.
 IPR018064; Metalthion_vert_metal_BS. 
Pfam
 PF00131; Metallothio 
SMART
  
PROSITE
 PS00203; METALLOTHIONEIN_VRT 
PRINTS
 PR00860; MTVERTEBRATE.