UniProt Accession

 DFFA_HUMAN; O00273; Q5T6G5; Q5T6G6; Q96I97; Q9Y6C6 

Genbank Protein ID

 U91985; AF087573; AF103799; BT006980; AK313317; AL354956; AL354956; CH471130; CH471130; BC000037; BC007112; BC007721 

Genbank Nucleotide ID

 AAC51249.1; AAD32953.1; AAF02419.1; AAP35626.1; BAG36122.1; CAI19196.1; CAI19197.1; EAW71656.1; EAW71657.1; AAH00037.1; AAH07112.1; AAH07721.1 

Protein Name

 DNA fragmentation factor subunit alpha 

Protein Synonyms/Alias

 DNA fragmentation factor 45 kDa subunit; DFF-45; Inhibitor of CAD; ICAD 

Gene Name

 DFFA 

Gene Synonyms/Alias

 DFF1; DFF45; H13 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
248	ILTALREKQAPELSL	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Inhibitor of the caspase-activated DNase (DFF40). 

Sequence Annotation

 DOMAIN 17 96 CIDE-N.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 315 315 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 331 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0000790; C:nuclear chromatin; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0004536; F:deoxyribonuclease activity; TAS:ProtInc.
 GO:0006309; P:apoptotic DNA fragmentation; IDA:MGI.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; TAS:ProtInc.
 GO:0043066; P:negative regulation of apoptotic process; IDA:BHF-UCL. 

Interpro

 IPR003508; CAD.
 IPR027296; DFF-C_dom.
 IPR017299; DNA_fragmentation_factor_asu.
 IPR015121; DNA_fragmentation_mid_dom. 

Pfam

 PF02017; CIDE-N
 PF09033; DFF-C 

SMART

 SM00266; CAD 

PROSITE

 PS51135; CIDE_N 

PRINTS