CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026984
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Utx, isoform B 
Protein Synonyms/Alias
 Utx, isoform C 
Gene Name
 Utx 
Gene Synonyms/Alias
 CG5640; Dmel_CG5640 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
385YKQNESIKLERLSQDacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 939 AA 
Protein Sequence
MLKHCGEFHI ALKHLQLALL YTYPSTFSEL QVKFQIAHLY EVQNKHKAAK DGYEFLLNEK 60
NISLELKADV YRQLGWMYHC VECLGEKKER EANALNFLQK SIEADPKSGQ SLYLLGRCYA 120
GINKVHDAFL AYRNSVEKSE GNADTWCSIG VLYQQQNQPT DALQAYICAV QLDKDHKAAW 180
TNLGILYESC GQLRDAYACY LNATKQISFQ KSSLIRKKQA IRMKKDTIGL SKGLSQRITF 240
LEGQLSQAPL PSITSKRRQL CSIEEAWNLP ISLEMNSRQQ QTAQMLPRQV TKQSPVQGPP 300
PPYPHSQLSQ SPIPSKRIKE DGTSQQEVTQ NNSQTSAQNL INISESLNQR NFNAMPESNK 360
SSEQSVLDTF DDISNDIYKQ NESIKLERLS QDALSNNEDS RHDFIGGDNA DISTTFKIQM 420
DSKQLMVAVK LLPIDEPPVH CTILQVNAPP PSPPDCPPQK LTRDQLLPPT PSVHLENKKH 480
AFSPQLQEFC LKHPIAVVRG LAGVLKLDLG LFSTKTLVEA NPDHSVEVRT QVHQSPDENW 540
DTSQGKRVWA CISHRSHTTI AKYAQYQASS FQDSLKLILP QDESDKGFPG SQAMSDSDSK 600
DSVSNSNIVL KRKKHKINSK MLRFGTNVDL SDEKKWKPQL TELQKLPAFA RVISAANMLS 660
HVGHVILGMN TVQLYMKVPG SRTPGHQENN NFCSININIG PGDCEWFAVP DAYWGGVHNL 720
CEKNNISYLH GSWWPVLEDL YKENIPVYRF IQKPGDLVWV NAGCVHWVQS IGWCNNIAWN 780
VGPLTARQYS LAIERYEWNK VQAFKSIVPM VHLSWNLARN IKVSDTKLFE LIKMCLLQTL 840
KNVLHIQEYV KSKGVEIRFN GRGKNEASHY CGQCEVEVFN VLFIKEQEKR HVVHCLSCAL 900
KLSPSLQGIV CLEEYRLSEL QRVYDSFTLH RTQGLAYTQ 939 
Gene Ontology
 GO:0044666; C:MLL3/4 complex; IDA:FlyBase.
 GO:0005705; C:polytene chromosome interband; IDA:FlyBase.
 GO:0071557; P:histone H3-K27 demethylation; IMP:FlyBase.
 GO:0051568; P:histone H3-K4 methylation; IDA:FlyBase.
 GO:0008285; P:negative regulation of cell proliferation; IMP:FlyBase.
 GO:0061086; P:negative regulation of histone H3-K27 methylation; IMP:FlyBase.
 GO:0045746; P:negative regulation of Notch signaling pathway; IGI:FlyBase.
 GO:0045498; P:sex comb development; IMP:FlyBase.
 GO:0042060; P:wound healing; IMP:FlyBase. 
Interpro
 IPR003347; JmjC_dom.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF02373; JmjC 
SMART
 SM00558; JmjC
 SM00028; TPR 
PROSITE
 PS51184; JMJC
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS