| Tag | Content |
|---|
| CPLM ID | CPLM-012945 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ATPase family AAA domain-containing protein 3 |
Protein Synonyms/Alias | |
Gene Name | Atad3 |
Gene Synonyms/Alias | Atad3a |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 134 | ARAQYQDKLARQRYE | acetylation | [1] | | 490 | LVRMYFDKYVLKPAT | acetylation | [1] | | 494 | YFDKYVLKPATEGKQ | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone- dependent steroidogenesis (By similarity). |
Sequence Annotation | NP_BIND 351 358 ATP (Potential).
REGION 1 49 Required for interaction with the inner
REGION 289 304 S100B-binding (By similarity).
MOD_RES 490 490 N6-acetyllysine (By similarity).
MOD_RES 512 512 N6-acetyllysine (By similarity). |
Keyword | Acetylation; ATP-binding; Coiled coil; Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Mitochondrion nucleoid; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 591 AA |
Protein Sequence | MSWLFGIKGP KGEGTGPPLP LPPAQPGAES GGDRGAGDRP SPKDKWSNFD PTGLERAAKA 60
ARELEHSRHA KEALNLAQMQ EQTLQLEQQS KLKEYEAAVE QLKSEQIRVQ AEERRKTLNE 120
ETRQHQARAQ YQDKLARQRY EDQLKQQQLL NEENLRKQEE SVQKQEAIRR ATVEREMELR 180
HKNEMLRVEA EARARAKADR ENADIIREQI RLKAAEHRQT ILESIRTAGT LFGEGFRAFV 240
TDWDKVTATV AGLTLLAVGV YSAKNATSVA GRYIEARLGK PSLVRETSRI SVLEALRHPI 300
QVSRRLVSRP QDALEGVILS PSLEARVRDI AIATRNTKKN KSLYRNVLMY GPPGTGKTLF 360
AKKLALHSGM DYAIMTGGDV APMGREGVTA MHKVFDWAST SRRGLLLFVD EADAFLRKRA 420
TEKISEDLRA TLNAFLHRTG QHSNKFMLVL ASNQPEQFDW AINDRIDEMV CFALPQREER 480
ERLVRMYFDK YVLKPATEGK QRLKVAQFDY GKKCSEVAQL TAGMSGREIA QLAVAWQAMA 540
YSSEDGVLTE AMMDARVQDA VQQHQQKMQW LKVERPDSEA SKPPHPSLLS C 591 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. GO:0042645; C:mitochondrial nucleoid; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |